Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection.

Antimicrob Agents Chemother

Department of Prion Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

Published: June 2007

Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891374PMC
http://dx.doi.org/10.1128/AAC.00917-06DOI Listing

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