AI Article Synopsis
- The study aimed to assess shortened rabies vaccination schedules that could lower costs and speed up completion time.
- A group of 96 participants, including veterinary students and healthcare workers, were given various abbreviated rabies vaccine schedules and had their antibody levels measured over time.
- All participants maintained detectable antibody levels for a year and showed a quick response to booster shots, suggesting that a one-week vaccination regimen might effectively create long-term immunity.
Article Abstract
Objective: To evaluate abbreviated preexposure rabies vaccination schedules that would reduce cost and shorten time required for completion.
Method: A random prospective immunogenicity study, using a group of 96 volunteer preclinical veterinary students, primary school children, and hospital-based health care workers. They were divided into six groups and administered abbreviated schedules of preexposure tissue culture rabies vaccines. Neutralizing antibodies were determined on days 0 and 360, and following boosters on days 367 and 374.
Results: All subjects, including one group that received only 0.1 mL intradermally at two sites on one day, had detectable neutralizing antibody titers 1 year later and responded with an accelerated antibody response when given booster injections.
Conclusion: It might be possible to develop a 1-week and even one clinic visit preexposure vaccine schedule that would provide at least 1 year of immune memory.
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| http://dx.doi.org/10.1111/j.1708-8305.2007.00120.x | DOI Listing |
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