Clopidogrel has an established and important role in the management of patients with coronary artery disease after an acute event. It is generally a well-tolerated drug. The major common problem associated with its use is the increased incidence of bleeding complications during or after coronary artery bypass graft surgery when clopidogrel is used within five days before surgery. For this reason, it is recommended to stop clopidogrel at least five days, and preferably one week before surgery.
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