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What's hot in neonatal respiratory monitoring?
Pediatr Res
November 2024
Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Respiratory monitoring is an essential part of routine clinical care of the newborn. Recent technological developments have improved respiratory monitoring and allowed for a two-way interaction between the monitored parameter and the level of the provided respiratory support. We herein discuss applications of monitoring by neurally adjusted ventilatory assist, closed-loop oxygen control, tidal capnography, lung ultrasound, diaphragmatic electromyography and lung magnetic resonance imaging.
View Article and Find Full Text PDFChronic diesel exhaust exposure induced pulmonary vascular remodeling a potential trajectory for traffic related pulmonary hypertension.
Respir Res
September 2024
Department of Pulmonary and Critical Care Medicine, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, 266071, China.
Article Synopsis
- - Diesel exhaust (DE) is a major traffic-related pollutant linked to increased risks for heart and lung diseases, but its specific effects on the small pulmonary vessels remain uncertain.
- - A study analyzed pulmonary vessel changes in workers exposed to DE and used a rat model to further investigate chronic DE exposure's impact, finding significant changes in pulmonary vessel structure and function.
- - Results indicated that DE exposure not only remodels the airways but also affects pulmonary vascular structure, contributing to overall dysfunction in heart and lung health.
GSH-responsive polymeric micelles-based augmented photoimmunotherapy synergized with PD-1 blockade for eliciting robust antitumor immunity against colon tumor.
J Nanobiotechnology
September 2024
State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Tianjin Institutes of Health Science, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, China.
Article Synopsis
- Phototherapy, which includes photothermal therapy (PTT) and photodynamic therapy (PDT), faces challenges in effectiveness due to tumor hypoxia and the presence of immunosuppressive factors like IDO and PD-L1.
- Researchers developed multifunctional polymeric micelles called RIMNA to deliver a combination of treatments: the photosensitizer ICG, an oxygenator MnO, an IDO inhibitor NLG919, and an immune stimulant MPLA.
- RIMNA showed strong stability and biocompatibility, and effectively improved phototherapy outcomes by enhancing immune activation and reducing tumor growth, indicating a promising strategy for improving cancer treatment.
What's behind thoracic surgery explosion in young patients under the age of 40 in Wuhan after COVID-19 outbreak?
Lung Cancer
October 2024
Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology. Wuhan 430030, Hubei, PR China. Electronic address:
Introduction: The COVID-19 pandemic was associated with a dramatic increase of chest CT scanning in Wuhan. This was partly a COVID effect: some private and public employers required employees to have CT examinations to confirm they were healthy before going back to work. But it also likely reflects the growing enthusiasm for low-dose computed tomography (LDCT) screening.
View Article and Find Full Text PDFTargeting ALDH2 to augment platinum-based chemosensitivity through ferroptosis in lung adenocarcinoma.
Free Radic Biol Med
November 2024
Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:
Ferroptosis is a regulated cell death driven by iron-dependent lipid peroxidation and associated with drug resistance in lung adenocarcinoma (LUAD). It's found that aldehyde dehydrogenase 2 (ALDH2), which is highly mutated in East Asian populations, is correlated with response to chemotherapy in LUAD patients. The rs671 variant knock-in, downregulation, and pharmacological inhibition of ALDH2 render LUAD cells more vulnerable to ferroptosis inducers and platinum-based chemotherapy.
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