A comparative study was performed on the initial and final bacillary indexes of 213 multibacillary leprosy patients who received 12 doses (Group 1: 128 patients) or 24 doses (Group 2: 85 patients) of multidrug therapy (MDT/WHO) to measure the effectiveness of the two regimens. All patients were evaluated at treatment baseline, 12 months, and 24 months. The reduction in bacillary levels and mean bacillary indexes at 24 months was similar in the two groups. No statistical difference in reaction rates was observed between the two treatment regimens.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s0102-311x2007000400009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Impact of histopathological and serological assessments on early diagnosis of leprosy relapse.
APMIS
January 2025
National Reference Center for Leprosy/Dermatological Health (CREDESH), HC-UFU/EBSERH, Uberlândia, Brazil.
This study aimed to identify laboratory factors predicting leprosy relapse (LR) after multi-drug therapy (MDT). A case-control study included 80 patients treated with MDT at a national reference center over 12 years. The Relapse Group had 40 patients who relapsed after an average of 89.
View Article and Find Full Text PDFEl Niño southern oscillation, weather patterns, and bacillary dysentery in the Yangtze River Basin, China.
Glob Health Res Policy
November 2024
Vanke School of Public Health, Tsinghua University, Haidian District, 100084, Beijing, China.
Article Synopsis
- This study explores how climate variability patterns, specifically the El Niño-southern oscillation (ENSO), affect the incidence of bacillary dysentery (BD) in China's Yangtze River Basin from 2005 to 2020.
- Both El Niño and La Niña events were found to raise the risk of BD, with increased regional temperatures and rainfall identified as contributing factors.
- The research highlights the importance of understanding the meteorological pathways influenced by ENSO to improve health responses and develop early warning systems for BD outbreaks.
Determining the extent and duration of infectiousness of individuals with pulmonary tuberculosis (TB) is critical for various aspects of TB care, including decisions regarding isolation. Studies suggest considerable heterogeneity in infectiousness of people with pulmonary TB. Pre-treatment, measures of bacillary burden including sputum smear microscopy, culture time-to-positivity, and Xpert MTB/RIF cycle threshold (Ct) value, predict the risk of transmission to contacts.
View Article and Find Full Text PDFProtective effects and mechanisms of HuDiChangRong capsule on TNBS-induced ulcerative colitis in mice.
J Ethnopharmacol
January 2025
Chinese Pharmacopoeia Commission, Beijing, 100061, China. Electronic address:
Ethnopharmacological Relevance: UC, characterized by chronic inflammation primarily affecting the colon and rectum, follows a protracted relapsing course marked by inflammation and an abundance of free radicals at the onset. Hudichangrong Capsule (HDCRC), a traditional Chinese medicinal formula, has long been employed in the treatment of UC and chronic bacillary dysentery, exhibiting positive therapeutic outcomes and a high rate of cure in clinical practice.
Aim Of The Study: The precise mechanism underlying its efficacy for UC remains elusive.
Role of histopathological, serological and molecular findings for the early diagnosis of treatment failure in leprosy.
BMC Infect Dis
October 2024
Post-Graduation Program in Health Science, School of Medicine, Federal University of Uberlândia, Uberlândia, MG, Brazil.
Background: Treatment failure (TF) in leprosy following multidrug therapy (MDT) presents a significant challenge. The current World Health Organization (WHO) fixed-duration MDT regimen, based on lesion count, might not be adequate. Leprosy lacks clear-cut objective cure criteria, and the predictive value of post-MDT histopathological findings remains uncertain.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!