AI Article Synopsis
- A subgroup of patients may present diabetic ketoacidosis at the start of diabetes but later be categorized as type 2 diabetes based on follow-up.
- These patients, often obese and of African or Hispanic descent, test negative for auto-antibodies linked to type 1 diabetes but often show specific HLA class II genetic markers.
- The text discusses a case of a Caucasian patient who experienced this shift and was able to discontinue insulin therapy, exploring factors that contributed to this positive outcome.
Article Abstract
A subgroup of patients presents diabetic ketoacidosis at the onset of diabetes mellitus (DM) but later is classified as type 2 DM based on the clinical follow-up. These individuals, most commonly obese of African or Hispanic origin, have negative auto-antibodies associated with type 1 DM, but frequently HLA class II DRB1*03 and/or DRB1*04 are detected. This peculiar subtype of DM is commonly referred to as diabetes flatbush. Here we report the case of a Caucasian patient that exhibited the described evolution and in whom it was possible to withdraw insulin therapy. The possible factors associated with this favorable development are also discussed.
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Article Synopsis
- Flatbush diabetes is an emerging and significant type of diabetes that is gaining attention worldwide, often confused with type 1 diabetes due to similar symptoms.
- It's important to recognize the differences between Flatbush diabetes, type 1, and type 2 diabetes for better early diagnosis and treatment strategies.
- A rare case study highlighted a young male experiencing recurrent diabetic ketoacidosis (DKA) during febrile illnesses, underscoring the need for more awareness and research on Flatbush diabetes.
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Endocrinology, State University of New York Downstate Medical Center, New York, USA.
Diabetic ketoacidosis (DKA) is a triad of uncontrolled hyperglycemia, metabolic acidosis, and increased total body ketone concentration. It is a well-known manifestation of type 1 diabetes mellitus (T1DM). However, it can also be the first presentation of type 2 diabetes mellitus (T2DM).
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January 2022
Epidemiology and Public Health, Allergy, Asthma and Chest Center, Mysore, IND.
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