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Neonates With In-Utero SSRI Exposure (NeoWISE): a retrospective cohort study examining the effect of newborn feeding method on newborn withdrawal.
Int J Popul Data Sci
December 2024
School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.
Introduction: Up to 30% of newborns with in-utero selective serotonin reuptake inhibitor (SSRI) exposure experience withdrawal symptoms. The impact of newborn feeding method on alleviating withdrawal has not been investigated. We examined the effect of newborn feeding method (breastfeeding versus formula) among a cohort of nates ith n-utero SRI xposure (NeoWISE).
View Article and Find Full Text PDFIntestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood.
Gastroenterology
December 2024
NYU Pain Research Center, Department of Molecular Pathobiology, College of Dentistry, New York University, New York, New York; Department of Cell Biology, NYU Grossman School of Medicine; New York, New York; Department of Pediatrics, NYU Grossman School of Medicine; New York, New York. Electronic address:
Background & Aims: Mood disorders and disorders of gut-brain interaction (DGBI) are highly prevalent, commonly comorbid, and lack fully effective therapies. Although selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for these disorders, they may impart adverse effects, including anxiety, anhedonia, dysmotility, and, in children exposed in utero, an increased risk of cognitive, mood, and gastrointestinal disorders. SSRIs act systemically to block the serotonin reuptake transporter and enhance serotonergic signaling in the brain, intestinal epithelium, and enteric neurons.
View Article and Find Full Text PDFPrenatal exposure to selective serotonin reuptake inhibitors and risk of disorders of gut-brain interaction in children.
Mol Psychiatry
December 2024
Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Preclinical data suggest that gestational exposure to selective serotonin reuptake inhibitors (SSRI) alter gut innervation, and delays colonic motility. In this study we investigated associations between gestational SSRI exposure and offspring disorders of gut-brain interaction (DGBI). Using population-based registries, we included all single-birth Danish children born 1997-2015 with follow-up until outcome occurrence, age 15 years, death, emigration, or December 2018.
View Article and Find Full Text PDFEffects of antidepressant type on allostatic load of male and female psychiatric outpatients.
J Psychiatr Res
November 2024
Mood and Anxiety Clinic Disorders, Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada.
Sex differences and antidepressant use are not systematically accounted for in studies measuring physiological dysregulations associated with chronic stress and allostatic load (AL) in neuropsychiatry. Critically, assessing commonly prescribed antidepressant medications, such as selective serotonin reuptake inhibitors (SSRIs) and selective serotonin and norepinephrine reuptake inhibitors (SNRIs) could help monitor potential iatrogenic effects on AL and health that are associated with prolonged antidepressant use. The objective of this exploratory analysis was to investigate how male and female psychiatric outpatients using either SSRIs or SNRIs differ in their AL indices.
View Article and Find Full Text PDFMaternal Daphnia magna exposure to the antidepressant sertraline causes molting disorder, multi-generational reproductive and serotonergic dysfunction.
Aquat Toxicol
January 2025
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, 712100, China. Electronic address:
Article Synopsis
- Sertraline, a commonly used antidepressant, has seen increased usage, particularly during the COVID-19 pandemic, prompting a study on its transgenerational effects using the aquatic microcrustacean Daphnia magna.
- The study found that exposure to sertraline influenced reproductive traits and molting behaviors in D. magna, with effects being inherited across three generations, including increased fecundity and body size reduction in offspring.
- Results indicated that sertraline's reproductive toxicity may be linked to serotonin dysregulation and that it triggered a self-defense reproductive response, although male offspring were not produced in the study across generations, suggesting complex interactions between the drug and population dynamics.
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