AI Article Synopsis
- A family experiencing recurrent spontaneous abortions was studied and found to have a new heritable fragile site at chromosome 15q13.
- This fragile site was present in nine individuals across three generations and was highly expressed in their cells, showing up in 88-95% of metaphase preparations.
- The expression of this fragile site remained consistent even in conditions of folate deficiency.
Article Abstract
Here, we describe a family ascertained through recurrent spontaneous abortions in which a new heritable fragile site located at 15q13 is segregating. The fragile site was present in nine members of a three-generation family and expressed spontaneously in a high proportion of the metaphases varying from 88 to 95% under standard culture conditions in all the carriers. This didn't change under folate deficiency.
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| http://dx.doi.org/10.1159/000100408 | DOI Listing |
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