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Tofacitinib as maintenance therapy for refractory Neurosarcoidosis.
Acta Neurol Belg
November 2024
Department of Internal Medicine and Infectious Diseases, Cliniques Universitaires Saint-Luc, UCLouvain, Avenue Hippocrate 10, 1200, Brussels, Belgium.
Neurosarcoidosis: Current Perspectives on Diagnosis, Management, and Future Directions.
Cureus
September 2024
Internal Medicine, Rawalpindi Medical University, Rawalpindi, PAK.
Article Synopsis
- Neurosarcoidosis is a rare form of sarcoidosis that affects the nervous system, leading to symptoms like seizures, cognitive issues, and cranial nerve problems, which complicate diagnosis and management due to their variability.
- Diagnosing the condition requires a mix of clinical assessments, advanced imaging (like high-resolution MRI and PET scans), and lab tests, but it can be mistaken for conditions like multiple sclerosis.
- Treatment often starts with corticosteroids and may include immunosuppressants or biologic therapies for more severe cases, with ongoing research aimed at better understanding the disease and improving therapies through biomarkers and innovative technologies.
Extrapulmonary sarcoidosis.
J Autoimmun
December 2024
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.
Article Synopsis
- - Sarcoidosis is a chronic inflammatory disease that arises in genetically susceptible individuals after exposure to certain antigens, primarily affecting the lungs but potentially impacting any organ, including the heart, nervous system, and eyes, which can lead to severe complications.
- - Diagnosis is typically easier when typical symptoms and biopsy findings are present, but it becomes more complex when symptoms manifest in areas outside the lungs without accompanying lung issues.
- - First-line treatment for sarcoidosis involves corticosteroids, while immunosuppressive or biologic medications are used for patients who do not respond to steroids or have refractory disease.
Non-infectious hypertrophic pachymeningitis associated with orbital inflammatory disease: a pooled analysis.
Orbit
August 2024
Department of Ophthalmology, The Royal Adelaide Hospital, Adelaide, Australia.
Purpose: To describe four cases of non-infectious hypertrophic pachymeningitis (HP)-associated with orbital inflammatory disease (OID). This study summarises the clinico-radiological features, outcomes, and management of HP-associated OID.
Methods: Retrospective case-series of patients with radiological evidence of HP and OID.
Neurosarcoidosis-induced winging scapula: Efficacy of infliximab treatment in addressing multifaceted challenges.
Mod Rheumatol Case Rep
January 2025
Department of Rheumatology, University of Central Florida College of Medicine, Orlando, FL, USA.
Sarcoidosis, a systemic granulomatous disease primarily affecting the respiratory and lymphatic systems, can rarely manifest as neurosarcoidosis either in isolation or alongside other systemic symptoms. Here, we describe the case of a 45-year-old male with a history of recurrent sinusitis refractory to antibiotics, who presented to the emergency department with sinus congestion and dysphagia. Clinical examination revealed left lower motor neuron facial palsy and enlarged submandibular salivary glands.
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