In clinical trials, the methods for achieving an event or near-even distribution of important patient parameters have been tedious and often disappointing. In this paper, a computer program for minimizing differences between experimental groups with respect to such important parameters, based on a method described by Traves (Clin. Pharmacol. Ther. London 15, 443, 1974) is presented. The program is available from the author.

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http://dx.doi.org/10.1016/0010-4809(91)90018-rDOI Listing

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