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Dihydrotanshinone I improves cardiac function by promoting lymphangiogenesis after myocardial ischemia-reperfusion injury.
Eur J Pharmacol
January 2025
Academy of Integrated Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:
Dihydrotanshinone I (DHT) is an active ingredient derived from Salvia miltiorrhiza. Previous studies have demonstrated that DHT can improve cardiac function in rats with myocardial ischemia-reperfusion injury (IR). However, the mechanism by which DHT improves myocardial injury in rats still requires further research.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
John P. Hussman Institute for Human Genomics, Miller School of Medicine, Miami, FL, USA.
Background: We identified the missense variant Ser1038Cys (rs377155188) in the tetratricopeptide repeat domain 3 (TTC3) gene that segregate in a non-Hispanic white late onset Alzheimer disease (LOAD) family. This variant is predicted to be deleterious and extremely rare (MAF<0.01%).
View Article and Find Full Text PDFLimited Reconstructive Options of Jaw Osteomyelitis in the Osteopetrosis Patient Complicated by Blood Dyscrasia.
J Craniofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
Osteopetrosis is a rare systemic skeletal disorder characterized by increased bone density and mass resulting from suboptimal or impaired resorption of osteoclastic bone. Compromised bone marrow function and associated disorders of red blood cells contribute to hematopoietic abnormalities, which exacerbate the risk of complex, recurrent infections such as jaw osteomyelitis. This case report describes the treatment of a 68-year-old Korean female with autosomal-dominant osteopetrosis who presented with severe and persistent jaw osteomyelitis complicated by hematopoietic dysregulation.
View Article and Find Full Text PDFNurses Caring for ICU Patients With Intellectual Developmental Disabilities in the United States: An Interpretivist Narrative Analysis Using Western Story Arcs.
J Adv Nurs
January 2025
College of Nursing, Brigham Young University, Provo, USA.
Background: Understanding ICU nurses' experiences in caring for patients with intellectual developmental disabilities is crucial. Insights can inform supportive measures and training programs to enhance nurse well-being and patient population-specific outcomes.
Objective: The primary objective of this study was to explore and understand the lived experiences of nurses caring for patients with intellectual developmental disabilities.
Smoking-related complications in foot and ankle surgery: a systematic review.
Eur Rev Med Pharmacol Sci
December 2024
Department of Orthopedic Surgery and Traumatology, Cantonal Hospital Fribourg, University of Fribourg, Fribourg, Switzerland.
Objective: The detrimental effects of cigarette smoking on overall health are well-documented, with nicotine and carbon monoxide contributing to peripheral vasoconstriction and impaired oxygen delivery to tissues. This study reviews the impact of smoking on wound and bone healing, specifically in foot and ankle surgery, given its significant role as a modifiable risk factor for complications in orthopedic procedures.
Materials And Methods: A systematic literature review was conducted in May 2024 following PRISMA guidelines.
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