Background: N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist.
Aim: Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer.
Methods: Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine.
Results: Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown.
Conclusions: Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.
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| http://dx.doi.org/10.5507/bp.2006.033 | DOI Listing |
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