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[Clinical management of patients with cavernous malformations of the central nervous system: an update and recommendations for clinical practice].
Praxis (Bern 1994)
December 2024
Klinik für Neurochirurgie, Klinisches Neurozentrum, Universitätsspital Zürich.
Cerebral cavernous malformations are benign vascular anomalies of the central nervous system (CNS). The clinical presentation of a cavernoma depends on its location. The majority of patients with cavernomas are asymptomatic.
View Article and Find Full Text PDFSpontaneous Tumor Lysis Syndrome in a Thoracic Burkitt Lymphoma: A Case Report.
Cureus
November 2024
Hematology, Centro Hospitalar de Setúbal, Hospital de São Bernardo, Setúbal, PRT.
Burkitt lymphoma has a high proliferation rate and a significant risk of tumor lysis syndrome. Risk stratification and early identification are imperative since it is an oncological emergency. We report the case of a 20-year-old woman, without relevant past medical history, admitted to the Emergency Department with a three-week history of fatigue, chest discomfort, productive cough, night sweats, myalgia, odynophagia, and holocranial headache.
View Article and Find Full Text PDFSafety, pharmacokinetics, and early bactericidal activity of quabodepistat in combination with delamanid, bedaquiline, or both in adults with pulmonary tuberculosis: a randomised, active-controlled, open-label trial.
Lancet Infect Dis
November 2024
Otsuka Pharmaceutical Development & Commercialization, Rockville, MD, USA. Electronic address:
Background: Quabodepistat (formerly OPC-167832) showed potent activity in preclinical studies and in the first stage of an early bactericidal activity study in adults with smear-positive, drug-susceptible pulmonary tuberculosis. Stage 2 of this study was designed to evaluate the safety, tolerability, pharmacokinetics, and early bactericidal activity of quabodepistat in combination with delamanid, bedaquiline, or both versus rifampicin, isoniazid, ethambutol, and pyrazinamide combination therapy for 14 days.
Methods: Stage 2 of this open-label, active-controlled, randomised, parallel-group study was conducted at two research sites in South Africa in adults (aged 18-64 years) with drug-susceptible pulmonary tuberculosis.
An observational cross-sectional study on the characteristics of children and adolescents with non-specific spinal pain stratified by pain severity.
BMC Pediatr
November 2024
Integrative Spinal Research Group, Department of Chiropractic Medicine, Balgrist University Hospital and University of Zurich, Forchstr. 340, Zurich, 8008, Switzerland.
Background: Distinguishing self-limiting ('trivial') from potentially consequential spinal pain in childhood and adolescence is crucial to prevent over- or under-medicalization. The aim of this study was to stratify participants for severity of spinal pain and to investigate associations of pain severity with potential consequences of pain and some psychophysical and clinical factors.
Methods: In 2020 and 2021, children and adolescents took part in a voluntary population-based spine screening event across Switzerland organized by the Swiss Chiropractors Association.
Discovering Subtypes with Imaging Signatures in the Motoric Cognitive Risk Syndrome Consortium using Weakly-Supervised Clustering.
medRxiv
October 2024
Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, 10461, USA.
Introduction: Understanding the heterogeneity of brain structure in individuals with the Motoric Cognitive Risk Syndrome (MCR) may improve the current risk assessments of dementia.
Methods: We used data from 6 cohorts from the (N=1987). A weakly-supervised clustering algorithm called HYDRA was applied to volumetric MRI measures to identify distinct subgroups in the population with gait speeds lower than one standard deviation (1SD) above mean.
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