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R21 in Matrix-M adjuvant in UK malaria-naive adult men and non-pregnant women aged 18-45 years: an open-label, partially blinded, phase 1-2a controlled human malaria infection study.
Lancet Microbe
January 2025
Jenner Institute, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, UK.
Background: R21 is a novel malaria vaccine, composed of a fusion protein of the malaria circumsporozoite protein and hepatitis B surface antigen. Following favourable safety and immunogenicity in a phase 1 study, we aimed to assess the efficacy of R21 administered with Matrix-M (R21/MM) against clinical malaria in adults from the UK who were malaria naive in a controlled human malaria infection study.
Methods: In this open-label, partially blinded, phase 1-2A controlled human malaria infection study undertaken in Oxford, Southampton, and London, UK, we tested five novel vaccination regimens of R21/MM.
Mapping the Genetic Architecture of the Adaptive Integrated Stress Response in .
bioRxiv
December 2024
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
The integrated stress response (ISR) is a conserved eukaryotic signaling pathway that responds to diverse stress stimuli to restore proteostasis. The strength and speed of ISR activation must be tuned properly to allow protein synthesis while maintaining proteostasis. Here, we describe how genetic perturbations change the dynamics of the ISR in budding yeast.
View Article and Find Full Text PDFPrognostic Factors Predicting Remission Following Rituximab Therapy for Pemphigus Vulgaris.
Acta Derm Venereol
January 2025
Department of Dermatology, Sheba Medical Center, Tel HaShomer, Ramat Gan, Israel.
Pemphigus vulgaris is a chronic autoimmune blistering disease with significant morbidity. Rituximab, approved as its first-line treatment, effectively induces remission. However, few studies have analysed the prognostic factors for improved rituximab outcomes.
View Article and Find Full Text PDFEffect of berry maturity stages on the germination and protein constituents of African nightshade (Solanum scabrum) seeds.
Sci Rep
December 2024
Institute of Horticultural Production Systems, Leibniz Universität Hannover, Herrenhäuser Straße 2, 30419, Hannover, Germany.
African nightshade (Solanum scabrum) is a vegetable of great importance in several African countries. Production by seed is constrained by limited access to high quality seed, leaving farmers unable to meet the growing demand. The aim of this study was to investigate effects of berry maturity stages (mature green and purple) on germination and protein components of African nightshade seeds.
View Article and Find Full Text PDFUnraveling the genetic basis of Rhizobium rhizogenes-mediated transformation and hairy root formation in rose using a genome-wide association study.
Plant Cell Rep
December 2024
Institute of Horticultural Production Systems, Section Woody Plant and Propagation Physiology, Leibniz University Hannover, Herrenhäuser Str. 2, 30419, Hannover, Germany.
Multiple QTLs reveal the polygenic nature of R. rhizogenes-mediated transformation and hairy root formation in roses, with five key regions explaining 12.0-26.
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