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Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
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Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
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File: /var/www/html/application/controllers/Detail.php
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Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
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Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
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Function: require_once
Objective: To observe changes of dopamine and its metabolite (3,4-hydroxyphenylaceticacid, DOPAC) levels of the brain regions in rats exposed by dimethoate (DM).
Methods: Groups of rats were treated with saline and 38.9, 83.7 and 180.0 mg/kg DM respectively, and were decapitated at different time course from 0.5 to 24 hours after the administration. The dopamine neurotransmitters and its metabolite were determined by reverse-phase high-performance liquid chromatography with electrochemical detection.
Results: The concentrations of DA (28% - 122% of control) and DOPAC (89% - 538% of control) varied according with the DM dose and the exposure time.
Conclusion: These results indicated that DM-induced toxic effects could alter the dopamine levels after the different dose and time exposure in the brain regions of rats.
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