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http://dx.doi.org/10.1038/nj7135-578a | DOI Listing |
Reprod Sci
January 2025
Rock Creek Medical Office, Kaiser Permanente Colorado, 280 Exempla Circle, Lafayette, Denver, CO, 80516, USA.
The primary objective of this study was to review a methotrexate 90-mg fixed-dose protocol for treatment of ectopic pregnancy, and to evaluate if any characteristics were associated with ectopic pregnancy treatment failure. This was a single arm retrospective cohort study conducted at Kaiser Permanente Colorado. The primary outcome was to describe rates of ectopic pregnancy treatment failure among patients who received fixed dose(s) of methotrexate for ectopic pregnancy between January 1, 2007 and August 31, 2017.
View Article and Find Full Text PDFEnergy Fuels
January 2025
Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, Washington 99354, United States.
The Co-Optimization of Fuels and Engines (Co-Optima) is a research and development consortia funded by the U.S. Department of Energy, which has engaged partners from national laboratories, universities, and industry to conduct multidisciplinary research at the intersection of biofuels and combustion sciences.
View Article and Find Full Text PDFJ Pers Soc Psychol
January 2025
Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine.
People who are higher in conscientiousness, extraversion, and agreeableness and lower in neuroticism tend to live longer. The present research tested the hypothesis that personality trait change in middle and older adulthood would also be associated with mortality risk, above and beyond personality trait level. Personality trait change may causally influence mortality risk through corresponding changes in health behaviors, social processes, and stress experience.
View Article and Find Full Text PDFGenes Dev
December 2024
Barbara Davis Center for Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA
Transcription factors (TFs) are indispensable for maintaining cell identity through regulating cell-specific gene expression. Distinct cell identities derived from a common progenitor are frequently perpetuated by shared TFs, yet the mechanisms that enable these TFs to regulate cell-specific targets are poorly characterized. We report that the TF NKX2.
View Article and Find Full Text PDFBMC Biol
January 2025
Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518120, China.
Background: Plant mitochondrial genomes (mitogenomes) exhibit extensive structural variation yet extremely low nucleotide mutation rates, phenomena that remain only partially understood. The genus Gossypium, a globally important source of cotton, offers a wealth of long-read sequencing resources to explore mitogenome and plastome variation and dynamics accompanying the evolutionary divergence of its approximately 50 diploid and allopolyploid species.
Results: Here, we assembled 19 mitogenomes from Gossypium species, representing all genome groups (diploids A through G, K, and the allopolyploids AD) based on a uniformly applied strategy.
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