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Prevalence and management of anemia and impact of treatment burden on health-related quality of life in chronic kidney disease and dialysis patients.
J Pharm Policy Pract
November 2024
Department of Pharmacy, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, People's Republic of China.
Article Synopsis
- - The study focused on anemia management in chronic kidney disease (CKD) patients in Pakistan, highlighting that 78.7% of CKD and 94.7% of dialysis patients experienced anemia, which significantly affects their quality of life (QoL).
- - A total of 170 patients participated, showing that while dialysis patients had higher usage of erythropoietin stimulating agents (ESAs), both groups faced a substantial treatment burden, which was linked to age, disease duration, and comorbidity.
- - The results indicated that many patients didn’t reach target hemoglobin levels after six months, suggesting inadequate management of anemia and illustrating a negative relationship between treatment burden and QoL for those undergoing dialysis.
Online Hemodiafiltration: A New Perspective for Patients With End-Stage Renal Disease.
Cureus
August 2024
Clinic of Maxillofacial Surgery, University Hospital "St. Marina", Varna, BGR.
Introduction Online hemodiafiltration (OL-HDF) is the most effective renal replacement therapy (RRT), which allows the enhanced removal of small and large uremic toxins by combining diffusion and convective transport of solutes. Although the goal of OL-HDF is to provide greater clearance of solutes with a preference for intermediate molecules responsible for many of the complications of chronic kidney disease (CKD), the studies reported to date and their meta-analyses are conflicting in nature and do not show a significant advantage of convective therapies on patient prognosis. Materials and methods At the Clinic of Nephrology and Dialysis, University Hospital "St.
View Article and Find Full Text PDFReinitiating Chemotherapy beyond Progression after Maintenance Immunotherapy in Extensive-Stage Small-Cell Lung Cancer.
Medicina (Kaunas)
July 2024
Department of Oncology-Palliative Care, "Sf. Luca" Chronic Diseases Hospital, 041915 Bucharest, Romania.
: Small-cell lung cancer (SCLC) is an aggressive form of cancer with a poor prognosis. The two-year survival rate is 8% of all cases. : We present the case of a male patient who was 50 years old at the time of diagnosis in May 2022.
View Article and Find Full Text PDFHypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors as a New Treatment Option for Anemia in Chronic Kidney Disease.
Biomedicines
August 2024
Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 90-549 Lodz, Poland.
Article Synopsis
- - Anemia significantly impacts chronic kidney disease (CKD) by lowering quality of life and raising cardiovascular risks, mainly due to low endogenous erythropoietin (EPO) and iron deficiencies.
- - Current treatment guidelines recommend using recombinant EPO and iron supplements, but new therapies like prolyl hydroxylase inhibitors (PHIs) are being explored to boost EPO production and improve iron use.
- - While HIF-PHIs (e.g., roxadustat, vadadustat) can increase hemoglobin levels in CKD patients and have beneficial effects on blood lipids, they may also lead to adverse effects like heart issues and require more research for safety and effectiveness.
Vitamin C-Dependent Uptake of Non-Heme Iron by Enterocytes, Its Impact on Erythropoiesis and Redox Capacity of Human Erythrocytes.
Antioxidants (Basel)
August 2024
Physiological Institute, Department of Vegetative and Clinical Physiology, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany.
In the small intestine, nutrients from ingested food are absorbed and broken down by enterocytes, which constitute over 95% of the intestinal epithelium. Enterocytes demonstrate diet- and segment-dependent metabolic flexibility, enabling them to take up large amounts of glutamine and glucose to meet their energy needs and transfer these nutrients into the bloodstream. During glycolysis, ATP, lactate, and H ions are produced within the enterocytes.
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