AI Article Synopsis
- CATERPILLER is a gene family in mammals characterized by NBD and LRR domains, playing a role in immune response regulation.
- Some members enhance inflammation, while others help decrease it, with evidence supporting these roles from shRNA/siRNA studies.
- The review centers on the Monarch-1/PYPAF7 gene, and briefly touches on several other related genes, including CLR16.2/NOD3, PYPAF2/PAN1/NALP2, and PYPAF3.
Article Abstract
CATERPILLER is a mammalian gene family with signature NBD and LRR domains. Several members of this family are positive regulators of inflammatory responses. Others, however, exert negative effects on proinflammatory responses. These data are particularly convincing when shRNA/siRNA are used. This review focuses on the Monarch-1/PYPAF7 gene with brief discussions of CLR16.2/NOD3, PYPAF2/PAN1/NALP2, and PYPAF3.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2238720 | PMC |
| http://dx.doi.org/10.1016/j.micinf.2007.01.018 | DOI Listing |
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Monarch-1/PYPAF7 and other CATERPILLER (CLR, NOD, NLR) proteins with negative regulatory functions.
Microbes Infect
April 2007
Lineberger Comprehensive Cancer Center, Department of Microbiology-Immunology, CB7295, University of North Carolina, Chapel Hill, NC 27599-7295, USA.
Article Synopsis
- CATERPILLER is a gene family in mammals characterized by NBD and LRR domains, playing a role in immune response regulation.
- Some members enhance inflammation, while others help decrease it, with evidence supporting these roles from shRNA/siRNA studies.
- The review centers on the Monarch-1/PYPAF7 gene, and briefly touches on several other related genes, including CLR16.2/NOD3, PYPAF2/PAN1/NALP2, and PYPAF3.
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals.
J Biol Chem
December 2005
Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
The CATERPILLER (CLR, also NOD and NLR) proteins share structural similarities with the nucleotide binding domain (NBD)-leucine-rich repeat (LRR) superfamily of plant disease-resistance (R) proteins and are emerging as important immune regulators in animals. CLR proteins contain NBD-LRR motifs and are linked to a limited number of distinct N-terminal domains including transactivation, CARD (caspase activation and recruitment), and pyrin domains (PyD). The CLR gene, Monarch-1/Pypaf7, is expressed by resting primary myeloid/monocytic cells, and its expression in these cells is reduced by Toll-like receptor (TLR) agonists tumor necrosis factor (TNF) alpha and Mycobacterium tuberculosis.
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