Shiftwork is a common experience for many workers. There are a wide range of shift systems in use, with a number of general approaches and myriad variations of each one. Many aspects of shift systems have been studied, but attempts to reach definitive conclusions about appropriate designs have been hampered by a number of methodological issues. The aim of this systematic review was to provide evidence-based recommendations on the effect of various shift systems on neurobehavioural and physiological functioning and to identify areas which are lacking in appropriate evidence. Two main aspects of shift design were able to be considered-the direction of shift rotation and extended shift length (mainly 12-h shifts). Other areas for which there was at least one relevant paper of adequate methodology were the use of naps during night shifts, the starting time of shifts, and several other specific shift issues. Overall, the review found there is insufficient evidence to support definitive conclusions regarding any of these factors. However, the analysis provides support for the use of forward rotating shift systems in preference to backward rotating shift systems, at last as far as 8-h shifts are concerned. There are many unanswered questions in shift design. For these questions to be answered, it is important that the methodological shortcomings present in most of the studies published to date be overcome.
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http://dx.doi.org/10.1016/j.smrv.2006.11.001 | DOI Listing |
BMC Pregnancy Childbirth
January 2025
Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
Background: Pregnancy has been increasingly recognized for its potential impact on cognitive function influenced significantly by hormonal fluctuations such as estrogen and progesterone. However, the findings from research in this area remain debated, often varying with individual factors and pregnancy trimesters.
Objective: This study aims to systematically review existing literature and empirical research to better understand the phenomenon known as "pregnancy brain" and its association with cognitive change.
Methods Mol Biol
January 2025
Natural Products Lab, Institute of Biology, Leiden University, Leiden, The Netherlands.
This introductory chapter traces the evolution of (bio)chemical assays, emphasizing the critical role of robust protocols in ensuring reproducibility-a fundamental aspect of scientific research. With the advent of systems biology, the need for standardized methods has intensified, particularly for integrating vast datasets in open-access formats. The historical progression from basic plant morphology to advanced chromatographic and spectroscopic techniques in phytochemistry highlights the necessity for precise, reproducible protocols.
View Article and Find Full Text PDFClin Neuroradiol
January 2025
Department of Neurology, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Purpose: Myocardial injury, indicated by an elevation of high-sensitive cardiac Troponin (hs-cTnT), is a frequent stroke-related complication. Most studies investigated patients with ischemic stroke, but only little is known about its occurrence in patients with intracerebral hemorrhage (ICH). This study aimed to assess the frequency, predictors, and implications of myocardial injury in ICH patients.
View Article and Find Full Text PDFCytokine Growth Factor Rev
January 2025
Faculty of Pharmacy, University of Ljubljana, Slovenia. Electronic address:
A cytokine storm is marked by excessive pro-inflammatory cytokine release, and has emerged as a key factor in severe COVID-19 cases - making it a critical therapeutic target. However, its pathophysiology was poorly understood, which hindered effective treatment. SARS-CoV-2 initially disrupts angiotensin signalling, promoting inflammation through ACE-2 downregulation.
View Article and Find Full Text PDFJ Neurointerv Surg
January 2025
Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
Background: Previous studies have shown that when thrombectomy has failed, rescue intracranial stenting is associated with better clinical outcomes compared with failed reperfusion. However, comparative data regarding stent type are lacking.
Objective: To compare the procedural and clinical outcomes of balloon-mounted stents (BMS) with those of self-expandable stents (SES).
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