AI Article Synopsis
- The study describes a process where alkaline protease, Bioprase, catalyzes the transesterification of arbutin with undecylenic acid vinyl ester to create a new arbutin derivative.
- The reaction rate is enhanced by increasing arbutin concentration, achieving over 90% conversion at a concentration of 0.9 M when combined with 2 M undecylenic acid vinyl ester.
- The resulting arbutin ester shows a significant ability to reduce melanin production in B16 melanoma cells, indicating potential applications in skin pigmentation management.
Article Abstract
Transesterification of arbutin and undecylenic acid vinyl ester was catalyzed by alkaline protease, Bioprase, in dimethylformamide to get arbutin derivative having undecylenic acid at 6-position of glucose moiety, 6-O-undecylenoyl p-hydroxyphenyl beta-D-glucopyranoside. The reaction rate increased with increase of arbutin concentration, and when its concentration was 0.9 M, the conversion rate was more than 90% under addition of 2 M undecylenic acid vinyl ester. The obtained arbutin ester significantly suppressed melanin production in murine B16 melanoma cells.
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| http://dx.doi.org/10.1016/j.bmcl.2007.03.039 | DOI Listing |
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