AI Article Synopsis
- Germline mutations in the fumarate hydratase (FH) gene lead to a condition called hereditary leiomyomatosis and renal cell cancer (HLRCC), characterized by renal cysts and specific tumor behaviors.
- Research on mice with inactive Fh1 in their kidneys revealed that these mutants developed renal cysts that showed increased levels of HIF1alpha and HIF2alpha, which are related to tumor growth and oxygen deficiency.
- The findings suggest that targeting pathways involving HIF overexpression and angiogenesis may offer new treatment options for HLRCC, as the mutated Fh1 directly drives pseudohypoxia in tumors.
Article Abstract
Germline mutations in the fumarate hydratase (FH) tumor suppressor gene predispose to leiomyomatosis, renal cysts, and renal cell cancer (HLRCC). HLRCC tumors overexpress HIF1alpha and hypoxia pathway genes. We conditionally inactivated mouse Fh1 in the kidney. Fh1 mutants developed multiple clonal renal cysts that overexpressed Hif1alpha and Hif2alpha. Hif targets, such as Glut1 and Vegf, were upregulated. We found that Fh1-deficient murine embryonic stem cells and renal carcinomas from HLRCC showed similar overexpression of HIF and hypoxia pathway components to the mouse cysts. Our data have shown in vivo that pseudohypoxic drive, resulting from HIF1alpha (and HIF2alpha) overexpression, is a direct consequence of Fh1 inactivation. Our mouse may be useful for testing therapeutic interventions that target angiogenesis and HIF-prolyl hydroxylation.
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| http://dx.doi.org/10.1016/j.ccr.2007.02.005 | DOI Listing |
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