Comparison of the domain-level organization of starch hydrolases and related enzymes.

Biochem J

Department of Chemistry, Carlsberg Laboratory, Copenhagen Valby, Denmark.

Published: November 1991

Structure-prediction and hydrophobic-cluster analysis of several starch hydrolases and related enzymes indicated the organization of eleven domain types. Most enzymes possess a catalytic (beta/alpha)8-barrel and a smaller C-terminal domain as seen in crystal structures of alpha-amylase and cyclodextrin glucanotransferase. Some also have a starch-granule-binding domain. Enzymes breaking or forming endo-alpha-1,6 linkages contain domains N-terminal to the (beta/alpha)8-barrel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1130598PMC
http://dx.doi.org/10.1042/bj2800051DOI Listing

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