AI Article Synopsis
- Understanding evolutionary changes is limited by poor databases of evolutionary anatomy and a lack of computational methods to identify candidate genes and regulators.
- Model organism studies benefit from shared ontologies in genomic databases, which help in organizing and using data effectively.
- Proposing the development of evolutionary and genomics databases to share information through common phenotype and anatomy ontologies could enhance research on genetic changes, character evolution, and biodiversity links to evolution and ecology.
Article Abstract
Understanding the developmental and genetic underpinnings of particular evolutionary changes has been hindered by inadequate databases of evolutionary anatomy and by the lack of a computational approach to identify underlying candidate genes and regulators. By contrast, model organism studies have been enhanced by ontologies shared among genomic databases. Here, we suggest that evolutionary and genomics databases can be developed to exchange and use information through shared phenotype and anatomy ontologies. This would facilitate computing on evolutionary questions pertaining to the genetic basis of evolutionary change, the genetic and developmental bases of correlated characters and independent evolution, biomedical parallels to evolutionary change, and the ecological and paleontological correlates of particular types of change in genes, gene networks and developmental pathways.
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| http://dx.doi.org/10.1016/j.tree.2007.03.013 | DOI Listing |
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