Cervical carcinoma is the third most common gynaecologic malignancy and is typically seen in younger women, often with serious consequences. The International Federation of Gynaecology and Obstetrics (FIGO) staging system provides worldwide epidemiologic and treatment response statistics. Magnetic resonance imaging (MRI), although not included officially in that system, plays an integral role in the evaluation of patients with cervical carcinoma. After the histological diagnosis has been made, MRI is recommended for noninvasive evaluation of tumor extent, often helping in designing optimal therapy. MRI renders excellent soft tissue contrast, allowing direct tumor visualization and assessment of tumor volume, depth of penetration, and extension to adjacent tissues. MRI obviates the use of invasive procedures such as cystoscopy and proctoscopy, especially when there is no evidence of local extension. MRI staging, when available, is invaluable for identifying important prognostic factors and optimising treatment strategies. The objective of this review is to discuss the MRI staging of the uterine cervical carcinoma, to propose a comprehensive, clinically relevant MRI examination for the assessment of uterine cervical carcinoma, and to present the correlation between MRI and pathologic imaging in comparison to the FIGO staging system.
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Head Neck Pathol
January 2025
Department of Oral and Maxillofacial Pathology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.
Purpose: This study aimed to investigate the role of DNA ploidy and proliferation index in distinguishing ameloblastoma (AB) from ameloblastic carcinoma (AC).
Methods: The study included 29 ACs, 6 conventional ABs that transformed into ACs, and a control cohort of 20 conventional ABs. The demographics and clinicopathologic details of the included cases were summarised and compared.
Reprod Sci
January 2025
Department of Radiation Oncology, Lianyungang No.2 People's Hospital, Lianyungang, China.
Cervical cancer (CC) represents a major gynecologic health problem. Respecting the role of programmed cell death ligand-1 (PDL-1) in cancer prognosis, we investigated its relationship with cervical squamous cell carcinoma (CSCC) invasion, metastasis and prognosis. A total of 184 CSCC patients were retrospectively selected, with normal paracarcinoma tissues as the Control group.
View Article and Find Full Text PDFCancer Lett
January 2025
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China. Electronic address:
This study aimed to investigate the associations of liquid-liquid phase separation (LLPS) and tumor stemness in hepatocellular carcinomas (HCC). LLPS-related genes were extracted from DrLLPS, LLPSDB and PhaSepDB databases. Stemness index (mRNAsi) was calculated based on the data from TCGA and Progenitor Cell Biology Consortium.
View Article and Find Full Text PDFInt J Surg Case Rep
January 2025
Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Electronic address:
Introduction And Importance: Cervical cancer is highly correlated with high-risk human papillomavirus (HPV) infection, accounting for approximately 70 % of cases. However, false-negative HPV test results can occur, complicating early detection.
Case Presentation: We introduce a rare case of cervical cancer with lung metastasis followed by vulvar metastasis.
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