Disorders in the compensatory adaptive processes underlie the development of many somatic diseases. The neuroimmunoendocrine complex and one of its main components, the hypothalamic-pituitary-adrenal system, play the leading role in the maintenance of the adaptation reserve. Treatment with a synthetic analog of hydrocortisone (final effector of this system) in low doses modulates its function by inducing positive changes in the adaptive mechanisms under conditions of stress exposure.
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