Auditory input to the right or left forebrain of adult male zebra finches (Taeniopygia guttata) was disrupted by lesioning the ipsilateral auditory relay nucleus of the thalamus. These birds were then presented with two kinds of auditory discriminations: (i) between their own song and the song of a cage mate; (ii) between two versions of an unfamiliar zebra finch song that differed only in the harmonic profile of one of the syllables. Right-side lesion birds did better than left-side lesion ones at discriminating between their own song and the song of a cage mate; left-side lesion birds did better on the harmonic profile task. We suggest that the two halves of the zebra finch brain process conspecific sounds differently, as seems to be the case for humans.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC48452 | PMC |
http://dx.doi.org/10.1073/pnas.89.4.1372 | DOI Listing |
PLoS Med
December 2024
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR.
Background: Clozapine is widely regarded as a highly efficacious psychotropic drug that is largely underused worldwide. Recent disproportionality analyses and nationwide case-control studies suggested a potential association between clozapine use and hematological malignancy (HM). Nevertheless, the absolute rate difference is not well-established due to the absence of analytic cohort studies.
View Article and Find Full Text PDFPlant Biotechnol J
February 2025
National Key Laboratory of Crop Genetic Improvement, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, China.
Recently, with the development of communication and positioning technologies, progressively higher demands have been placed on the timeliness of indoor communication and the effectiveness of indoor positioning. This paper proposes a low-cost and full-time domain coverage indoor communication and localization fusion system that uses an infrared camera to identify mobile LEDs based on region of interest optical camera communication (RoI-OCC) and calculate three-dimensional (3D) world coordinates based on perspective-n-point (PnP) algorithm. An intermediate delimiter modulation-demodulation method is designed to achieve asynchronous OCC.
View Article and Find Full Text PDFbioRxiv
October 2024
Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
The planar cell polarity (PCP) signaling pathway polarizes epithelial cells in the tissue plane by segregating distinct molecular subcomplexes to opposite sides of each cell, where they interact across intercellular junctions to form asymmetric clusters. The role of clustering in this process is unknown. We hypothesized that protein cluster size distributions could be used to infer the underlying molecular dynamics and function of cluster assembly and polarization.
View Article and Find Full Text PDFEur J Med Chem
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address:
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that severely diminishes the quality of life for millions. The NLRP3 inflammasome, a critical mediator of inflammation, has emerged as a promising therapeutic target for AD. In this study, we report the development and optimization of a novel series of sulfonylurea-based NLRP3 inhibitors, with a focus on compound MC1 for the treatment of AD.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!