The development of degradable bone cements with a mineral composition similar to natural bone was investigated using highly reactive calcium phosphate phases as starting materials. Mixtures of XRD-amorphous, glassy tricalcium phosphate (amorphous-TCP) nanoparticles of 25-60 nm size and micron sized, milled alpha-TCP were set by hydration with sodium phosphate buffer and investigated for possible application as single component calcium phosphate cements (CPCs). Isothermal calorimetry allowed a precise tracking of the setting process. Amorphous-TCP nanoparticles converted into calcium deficient hydroxyapatite with cement setting times below 12 min. The total energy release by the material during hardening corroborated the importance of high specific surface area and phase composition, that is, amorphous state of the nanometric starting material as repeatedly suggested earlier. The phase composition of the resulting CPCs was characterized by X-ray diffraction before and after setting. The morphology was investigated by nitrogen adsorption, scanning, and transmission electron microscopy and revealed the formation of highly porous calcium deficient hydroxyapatite with specific surface areas of up to 160 m(2) g(-1) after setting. In contrast to the very fast reaction time and highest specific surface area, the mechanical stability of the resulting CPC is still insufficient and requires further improvement.
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