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VEGF-C and VEGF-A synergistically enhance lymph node metastasis of gastric cancer. | LitMetric

AI Article Synopsis

  • * In a study of 80 gastric cancer patients, high levels of VEGF-C were found in 93.8% of cases, while VEGF-A was present in 51.3% of cases, with VEGF-A showing a strong correlation to factors like tumor differentiation and vascular invasion.
  • * The findings indicate that both VEGF-C and VEGF-A expressions are significant in predicting lymph node metastasis, suggesting that their combined effects may enhance the metastatic potential of gastric cancer.

Article Abstract

Purpose: Vascular endothelial growth factor C (VEGF-C) is the most important molecule in lymphangiogenesis and its relationship with lymph node metastasis has attracted considerable interest. We investigated the relationship of VEGF-C or VEGF-A with clinicopathological factors in gastric cancer patients.

Methods: Eighty gastric cancer patients who underwent gastric resection were analyzed immunohistochemically for expression of VEGF-C and VEGF-A protein.

Results: Positive immunoreactivity of VEGF-C and VEGF-A was observed in 75 (93.8%) and 41 (51.3%) patients, respectively. VEGF-A expression was significantly correlated with tumor differentiation (p=0.0017) and vascular invasion (p=0.0004). And positive relationship of VEGF-C expression was only demonstrated with tumor differentiation (p=0.0168). Interestingly, however, the frequency of lymph node metastasis was significantly higher in the patients with expression of both VEGF-C and VEGF-A (strong positive expression, p=0.036). Furthermore, the expression of both was also significantly correlated with depth of tumor invasion, tumor differentiation, lymphatic invasion, and vascular invasion.

Conclusion: The present results suggest that strong expression of VEGF-A in addition to VEGF-C expression is essential in lymph node metastasis, presumably because enhanced metastatic potential including lymphangiogenesis induced by both VEGF-A and VEGF-C is vital in lymph node metastasis of gastric cancer.

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Source
http://dx.doi.org/10.1248/bpb.30.633DOI Listing

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