We describe a novel approach for the use of a FilterWire EX distal protection device as a snaring device for clot extraction in a patient who sustained acute ST-elevation myocardial infarction due to occlusion of the right coronary artery.
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Evaluation of discrepancy between clot-based and chromogenic factor IX coagulation assays in non-severe hemophilia B patients and identification of the causing mutations.
Transfus Apher Sci
December 2024
Department of Hematology and Blood Banking, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:
Background: Hemophilia B, or Christmas disease, is a hemorrhagic inherited disorder. Previous studies have reported measurement discrepancies in factor VIII activity between clot-based and chromogenic assays in approximately one-third of patients with non-severe hemophilia A. However, similar discrepancies in hemophilia B have been less extensively studied.
View Article and Find Full Text PDFDual-stent thrombectomy for recanalization of cerebral embolism caused by infective endocarditis: a case report.
Front Neurol
December 2024
Department of Neurology, The Second People's Hospital of Liaocheng, The Second Hospital of Liaocheng Affiliated to Shandong First Medical University, Linqing, China.
Methods: In this case report, we present an in-depth narrative of a patient who was subjected to mechanical thrombectomy (MT) for an obstruction in the main trunk and bifurcation of the left middle cerebral artery subsequent to Infective Endocarditis (IE). Initial intervention using a solitary-stent technique proved to be ineffective; thus, we shifted to a dual-stent strategy, which successfully recanalized the compromised blood vessel.
Results: The dual-stent retriever method can be especially advantageous for treating persistent clots that occur at arterial bifurcations resisting the efforts of a single-stent retriever during the MT process.
Impact of direct oral anticoagulants on ROTEM® variables; a sample size-calculated experimental study.
Scand J Clin Lab Invest
December 2024
The Medical Faculty, Lund University Sweden. Sölveg, Lund, Sweden.
Direct oral anticoagulants (DOAC) are increasingly common, with bleeding events associated with elevated plasma concentrations. Rotational thromboelastometry (ROTEM), a point-of-care tool for assessing secondary hemostasis, has demonstrated a correlation with increasing concentrations of DOAC. However, previous studies have only partially explored this relationship.
View Article and Find Full Text PDFIsolation of methyl caffeate and flacourtin from with comprehensive and pharmacological evaluation.
Heliyon
December 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, 1000, Bangladesh.
Article Synopsis
- The Indian Coffee Plum (Flacourtia jangomas) is a medicinal plant known for its bioactive compounds and potential therapeutic benefits, prompting research into its extracts from bark for medical applications.
- The study involved extracting phytochemicals using methanol, conducting screenings, and comparing the biological activities of the extracts, revealing the presence of new compounds like methyl caffeate and flacourtin.
- Results showed the extract has strong antioxidant and cytotoxic properties, pain relief effects, and moderate thrombolytic action, but limited antibacterial and antifungal activities, indicating a need for further research on its bioactive compounds.
Hybrid Clot Histomic-Transcriptomic Models Predict Functional Outcome After Mechanical Thrombectomy in Acute Ischemic Stroke.
Neurosurgery
December 2024
Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo , New York , USA.
Background And Objectives: Histologic and transcriptomic analyses of retrieved stroke clots have identified features associated with patient outcomes. Previous studies have demonstrated the predictive capacity of histology or expression features in isolation. Few studies, however, have investigated how paired histologic image features and expression patterns from the retrieved clots can improve understanding of clot pathobiology and our ability to predict long-term prognosis.
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