Methotrexate peak level after intratubal injection was found to be significantly lower than the accepted toxic level. After IM injection, MTX peak level and the AUC were found to be similar to the levels observed after intratubal injection. The advantage of tubal injection over IM injection is challenged.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0015-0282(16)54923-1DOI Listing

Publication Analysis

Top Keywords

tubal injection
8
peak level
8
intratubal injection
8
injection
6
pharmacokinetics methotrexate
4
methotrexate local
4
local tubal
4
injection conservative
4
conservative treatment
4
treatment ectopic
4

Similar Publications

Background: Chronic salpingitis is one of the most common causes of female infertility. Luteal support is a critical step for embryo transfer. Here, we evaluated the effects of two luteal support regimens, intramuscular progesterone (IMP) and progesterone vaginal gel (VAG), on the pregnancy outcomes in patients with chronic salpingitis undergoing vitrified-warmed embryo transfer.

View Article and Find Full Text PDF
Article Synopsis
  • * Researchers compared the pregnancy outcomes of patients treated expectantly with those who had only eutopic pregnancies and those who underwent surgery, matching them based on age, previous pregnancies, and gestational age.
  • * The results showed similar rates of live births and early miscarriages among the expectant management group, the eutopic group, and the surgical group, indicating that expectant management may be a viable option for patients with heterotopic pregnancies.
View Article and Find Full Text PDF

Family planning behavior before and during the COVID-19 pandemic.

J Turk Ger Gynecol Assoc

December 2024

Department of Obstetrics and Gynecology, New York City Health + Hospitals/South Brooklyn Health, Brooklyn, NY, United States of America.

Article Synopsis
  • The study compared contraception use and follow-up visit data among women aged 18-49 in New York City before and during the COVID-19 pandemic, divided into three one-year periods.
  • Findings showed increased use of contraceptive implants during the early COVID-19 period without a vaccine, while usage of overall contraception and IUDs decreased when vaccines became available.
  • The results indicate shifts in contraceptive behavior due to the pandemic, emphasizing the need for healthcare providers to adapt to changing preferences during public health crises.
View Article and Find Full Text PDF

BACKGROUND Tubal infertility caused by proximal occlusion of fallopian tubes is a common cause of female infertility. Lipiodol (ethiodized oil) is an oil-based iodinated contrast medium, previously used in hysterosalpingography, and is now used as a therapeutic agent. This single-center study aimed to evaluate the experience of outcomes from the use of Lipiodol in 96 women with infertility due to fallopian tube occlusion.

View Article and Find Full Text PDF

Objective: To determine the clinical and embryo laboratory factors that affect the clinical pregnancy rate of infertile patients with endometriosis (EMs), and establish a model for predicting clinical pregnancy.

Study Design: An observational study. Place and Duration of the Study: Reproductive Medicine Centre, Jiangxi Provincial Maternal and Child Health Hospital, China, from January 2016 to December 2023.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!