The known alkaloids (+/-)-stylopine, (+/-)-sinactine, protopine, (+)-bulbocapnine, (-)-domesticine, (+)-corydine and (+)-isoboldine were found in the mixture of alkaloids from Corydalis marschalliana (Papaveraceae), growing in Bulgaria. The alkaloids dehydronantenine, (+)-nantenine and oxonantenine were isolated for the first time from this plant. The spectral data of these alkaloids are given. In addition, three unidentified alkaloids (Cm-4, Cm-11 and Cm-12), in a small quantities, were described.
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http://dx.doi.org/10.1055/s-2007-971718 | DOI Listing |
J Ethnopharmacol
January 2025
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. Electronic address:
Ethnopharmacological Relevance: Corydalisdecumbens (Thunb.) (CD) is a traditional Chinese medicine and as a single herb or formula has been used to treat RA for decades. Rheumatoid arthritis (RA) is a persistent, systemic autoimmune inflammatory disease.
View Article and Find Full Text PDFInt Immunopharmacol
January 2025
Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, P.R. China. Electronic address:
Background: Peripheral nerve injury (PNI) is a common clinical problem that can result in partial or complete loss of sensory, motor, and autonomic functions. Tetrahydropalmatine (THP), a Corydalis yanhusuo-derived phytochemical alkaloid, possesses hypnotic, soothing, analgesic, and other effects, but little is known about the effect of THP on moderating peripheral nerve regeneration and its possible underlying mechanism of action.
Purpose: In this study, we aim to elucidate the protective function of THP on PNI and further reveal the underlying pharmacological mechanisms.
Ecotoxicol Environ Saf
December 2024
Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Changning District, Shanghai 200336, China; Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 720 Xianxia Road, Changning District, Shanghai 200336, China. Electronic address:
The effects of chlormequat chloride, a typical plant growth regulator, on the medicinal herb Corydalis yanhusuo were investigated. A standardized field experiment was conducted to investigate the molecular mechanisms and variations in active compounds resulting from chlormequat chloride treatment. Samples of C.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
November 2024
Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital,Beijing University of Chinese Medicine Beijing 100700, China College of Pharmacy, Qinghai Minzu University Xining 810007, China.
Corydalis Rhizoma is a commonly used traditional Chinese medicine(TCM) for regulating Qi and relieving pain in clinical practice, with remarkable efficacy. However, its pharmacodynamic substances are not yet fully understood and require further research. In this study, 24 compounds were isolated and identified from the aqueous extracts of vinegar-processed Corydalis Rhizoma using techniques such as macroporous adsorption resin column chromatography, Sephadex LH-20 column chromatography, and semi-preparative high-performance liquid chromatography.
View Article and Find Full Text PDFPhytochemistry
December 2024
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, PR China. Electronic address:
Six isoquinoline alkaloids were identified from the alkaloid-rich fraction of Corydalis hendersonii Hemsl, including five previously undescribed isoquinoline alkaloids hendersines J-M (1a, 1b, and 2-4) and isobicuculline (5), a compound reported for the first time from a natural source. Their structures were elucidated based on spectroscopic analysis of HR-ESI-MS, 1D and 2D NMR, X-ray diffraction, and ECD. Compounds 1a and 1b represent a pair of rare three-nitrogen isoquinoline alkaloid enantiomers, while 2 and 3 are isoquinoline alkaloids featuring a benzo-fused N-heterocycle.
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