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Established and novel insights to guide cancer assessment in patients with idiopathic inflammatory myopathies.
Semin Arthritis Rheum
December 2024
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy; Rheumatology and Clinical Immunology, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS) Humanitas Research Hospital, Rozzano, Italy.
Objective: Older age, dermatomyositis, and specific serum autoantibodies such as anti-TIF1-γ are associated with higher cancer risk in patients with myositis. We evaluated a vast cohort of patients with myositis for the prevalence of cancer, the association to disease features, and the performance of the recent IMACS guidelines.
Methods: A retrospective cohort analysis was performed and in all cases serum autoantibodies were tested using HEp-2, immunoassays, RNA- and protein-immunoprecipitation.
MRI appearance of Bochdalek's flower basket in a patient with bilateral hippocampus infarct.
Radiol Case Rep
February 2025
Department of Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra, India, 442001.
The occurrence of isolated bilateral hippocampus infarct is extremely rare and is thought to be associated with a number of etiologies, including ischemia, infection, paraneoplastic syndromes, seizures, drug addiction, etc. The presented manuscript depicts a case of a 28-year-old male patient who has been a chronic alcoholic for the past 4 years and, on imaging, was found to have a bilateral hippocampal infarct in isolation. Also, the manuscript presents the appearance of the magnetic resonance imaging (MRI) of Bochdalek's flower basket, which is an anatomical variant of the choroid plexus in the fourth ventricle.
View Article and Find Full Text PDFA Case Report of Systemic Lupus Erythematosus Presenting as Isolated Mononeuropathy Multiplex.
Neurohospitalist
September 2024
Department of Neurology, Northwestern Memorial Hospital, Chicago, IL, USA.
Mononeuropathy multiplex is a pattern of progressive sensory and motor deficits in the distribution of two or more peripheral nerves. The differential for mononeuropathy multiplex includes vasculitis, autoimmune disorders, infectious diseases, sarcoidosis, amyloidosis, cryoglobulinemia, and paraneoplastic disease. We present a case of a 42-year-old woman with hypothyroidism who presented with 1 week of ascending numbness and weakness, persistent fevers, and 3 months of constant burning pain in both feet.
View Article and Find Full Text PDFAltered exosomal miRNA profiles in patients with paraneoplastic cerebellar degeneration.
Ann Clin Transl Neurol
December 2024
Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Article Synopsis
- The study explores the relationship between ovarian cancer (OC) and anti-Yo-associated paraneoplastic cerebellar degeneration (PCD), focusing on changes in exosomal microRNA (miRNA) profiles in OC patients with PCD compared to healthy individuals and those without PCD.
- Serum exosomes from three groups (OC with PCD, OC without PCD, and healthy controls) were analyzed, revealing 103 differentially expressed miRNAs in PCD patients versus OC patients without PCD, and 139 versus healthy controls.
- Key miRNAs such as miR-486-5p and miR-21-5p showed potential as biomarkers for diagnosing PCD and indicated a link between these miRNAs and the
Case report: hypertrophic osteoarthropathy improves with immune checkpoint inhibitor therapy.
J Chemother
October 2024
University of Alberta, Edmonton, Canada.
Article Synopsis
- A 66-year-old male with recurrent stage IIIA non-small cell lung cancer (NSCLC) developed hypertrophic osteoarthropathy (HOA) before starting immunotherapy.
- After receiving the immunotherapy drug durvalumab, the patient experienced significant relief from hand pain and complete resolution of his symptoms after five treatments.
- This case is notable because it suggests durvalumab could help manage HOA in NSCLC patients, highlighting a need for additional research into how immune-checkpoint inhibitors interact with HOA and other related conditions.
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