Thrombocytopenia related neonatal outcome in preterms.

Objective: To investigate the thrombocytopenia and platelet transfusion related outcome in very preterm infants.

Methods: Cases (n=94) with at least one episode of thrombocytopenia (platelet counts < 150 x 10(9)/L) and controls (n=70) were identified from a database of 1054 neonates with gestational age < or = 32 weeks admitted to a level III NICU. Thrombocytopenia and platelet transfusion related morbidity (IVH, sepsis, NEC, and bleeding) and mortality were analyzed with respect to gestational age (< 28 weeks and 28-32 weeks), severity of thrombocytopenia (mild if platelet count > or = 100 and < 150 x 10(9)/L, moderate if count > or = 50 and < 100 x 10(9)/L, and severe if platelets < 50 x 10(9)/L), age of thrombocytopenia onset (early < 72 hours and late > or =72 hours).

Results: The majority of thrombocytopenia (67.0%) was diagnosed after 72 hours of age, and was mild in 12.8%, moderate in 36.2% and severe in 51.0% of the cases. Neonates with severe and moderate thrombocytopenia were more frequently born at lower gestational age and birth weight. NEC and sepsis especially that caused by Candida infection, were associated with severe thrombocytopenic events. The development of IVH was strongly associated with lower gestational age but not the severity and age of thrombocytopenia onset. Mucocutaneous bleeding complicated 18.4% of cases with severe and late-onset thrombocytopenia (7/38). Platelets were transfused to 85.4% of infants with severe and 64.7% of infants with moderate thrombocytopenia (P< 0.02). The gestational age of the majority of the platelet transfused neonates (49/60, 81.7%) was < 28 weeks. Mean gestational age and birth weight, and rates of severe thrombocytopenia, IVH, sepsis and mortality were comparable in transfused vs not-transfused infants with gestational age 28-32 weeks. Platelet transfused neonates with gestational age < 28 weeks had lower birth weights, were more often severely thrombocytopenic, and died more frequently than infants of a similar gestational age who were not transfused.

Conclusion: Platelet transfusions did not lower mortality in very premature born infants with moderate and severe thrombocytopenia during the NICU admission.