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A Novel Polymer Film to Develop Heart Valve Prostheses.
Polymers (Basel)
November 2024
Icon Lab Gmbh Ltd., 1 Barrikad St., Nizhny Novgorod 603003, Russia.
Polymer heart valves are a promising alternative to bioprostheses, the use of which is limited by the risks of calcific deterioration of devitalized preserved animal tissues. This is especially relevant in connection with the increasingly widespread use of transcatheter valves. Advances in modern organic chemistry provide a wide range of polymers that can replace biological material in the production of valve prostheses.
View Article and Find Full Text PDFExperimental Study of Products Based on Biocompatible Polymer Material from Methacrylic Oligomers as a Potential Barrier for Preventing Adhesions in Cardiac Surgery.
Bull Exp Biol Med
November 2024
Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russia.
The effectiveness and safety of two types of samples based on a biocompatible polymer material made of methacrylic oligomers (Reperen) as a potential antiadhesion pericardial barrier were evaluated in in vitro and in vivo experiments. Two kinds of samples, reinforced with a polyamide mesh and without reinforcement, were used. In in vitro experiments, no adhesion and aggregation of human fibroblasts to the test samples were detected.
View Article and Find Full Text PDFUsing Polycaprolactone Nanofibers for the Proof-of-Concept Construction of the Alveolar-Capillary Interface.
J Biomed Mater Res A
January 2025
Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
The alveolar-capillary interface is the key functional element of gas exchange in the human lung, and disruptions to this interface can lead to significant medical complications. However, it is currently challenging to adequately model this interface in vitro, as it requires not only the co-culture of human alveolar epithelial and endothelial cells but mainly the preparation of a biocompatible scaffold that mimics the basement membrane. This scaffold should support cell seeding from both sides, and maintain optimal cell adhesion, growth, and differentiation conditions.
View Article and Find Full Text PDFOpen-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis.
Nat Protoc
October 2024
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Synthetic polypeptides, also known as poly(α-amino acids), have the same polyamide backbone structures as natural proteins and peptides. As an important class of biomaterials, polypeptides have been widely used because of their biocompatibility, bioactivity and biodegradability. Ring-opening polymerization of N-carboxyanhydride (NCA) is a classical and widely used method for the synthesis of polypeptides.
View Article and Find Full Text PDFAlginate and chitosan-based polyamide 56 modified nanofiber membrane for highly effective capture of Escherichia coli: Antibacterial and cytotoxicity studies.
Int J Biol Macromol
November 2024
Department of Chemical Engineering and Materials Science, Yuan Ze University, Zhongli Dist., Taoyuan City 320315, Taiwan. Electronic address:
In recent years, microbial fermentation has become a sustainable alternative to traditional petrochemical processes for producing biomass nylon 56 (i.e., PA56).
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