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Melatonin, modulation of hypothalamic activity, and reproduction.
Vitam Horm
January 2025
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina; Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address:
Light is the most reliable environmental cue allowing animals to breed successfully when conditions are optimal. In seasonal breeders, photoperiod (length of daylight) information is sensed by the eyes and transmitted to the suprachiasmatic nucleus, the master clock region located in the hypothalamus. This structure has a 24-h firing rhythm involving a cycle of clock protein synthesis and degradation, and provides the timing to synchronize the synthesis and release of melatonin, the chemical signal that transduces the photoperiod information.
View Article and Find Full Text PDFMenstrual cycle characteristics across the reproductive lifespan and cognitive function in midlife women.
Am J Obstet Gynecol
January 2025
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Background: Menstrual cycle characteristics are potential indicators of hormonal exposures and may also signal cardiovascular disease risk factors, both of which are relevant to cognitive health. However, there is scarce epidemiological evidence on the association between cycle characteristics and cognitive function.
Objectives: We studied the associations of menstrual cycle characteristics at three stages of a woman's reproductive lifespan with cognitive function in midlife.
Gait Analysis in Patients After Hemiepiphysiodesis Due to Valgus or Varus Knee Deformity.
J Clin Med
January 2025
Department of Orthopaedic and Trauma Surgery, Institute of Medical Sciences, University of Opole, 45-040 Opole, Poland.
Developmental knee joint deformities are a common problem in pediatric orthopedics. Children with a valgus or varus deformity of the distal femur or the proximal tibia are commonly treated with hemiepiphysiodesis. Gait analysis in patients with lower limb deformities plays an important role in clinical practice.
View Article and Find Full Text PDFStrain-Controlled Thermal-Mechanical Fatigue Behavior and Microstructural Evolution Mechanism of the Novel Cr-Mo-V Hot-Work Die Steel.
Materials (Basel)
January 2025
School of Materials Science and Engineering, Henan University of Science and Technology, Luoyang 471023, China.
In response to the intensifying competition in the mold market and the increasingly stringent specifications of die forgings, the existing 55NiCrMoV7 (MES 1 steel) material can no longer meet the elevated demands of customers. Consequently, this study systematically optimizes the alloy composition of MES 1 steel by precisely adjusting the molybdenum (Mo) and vanadium (V) contents. The primary objective is to significantly enhance the microstructure and thermal-mechanical fatigue performance of the steel, thereby developing a high-performance, long-life hot working die steel designated as MES 2 steel.
View Article and Find Full Text PDFMeasurement of pressure dependent variations in local pulse wave velocity within a cardiac cycle from forward travelling pulse waves.
Sci Rep
January 2025
Healthcare Technology Innovation Centre, Indian Institute of Technology Madras, Chennai, India.
The local pulse wave velocity (PWV) from large elastic arteries and its pressure-dependent changes within a cardiac cycle are potential biomarkers for cardiovascular risk stratification. However, pulse wave reflections can impair the accuracy of local PWV measurements. We propose a method to measure pressure-dependent variations in local PWV while minimizing the influence of pulse wave reflections.
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