Solution studies on the binding properties of uranyl ion toward four different recently synthesized benzo-substituted macrocyclic diamides L1-L4 revealed the occurrence of a 1:1 complexation of the ligands with UO(2)(2+) ion, with a stability order of L2>L1>L4>L3. Consequently, L2 was used as a suitable neutral ionophore for the preparation of novel polymeric membrane (PME) and coated graphite (CGE) UO(2)(2+)-selective electrodes. The electrodes exhibit a Nernstian behavior for UO(2)(2+) ions over wide concentration ranges (1.0 x 10(-6) - 1.0 x 10(-1) M for PME and 1.0 x 10(-7) - 1.0 x 10(-1) M for CGE) and very low limits of detection (8.0 x 10(-7) M for PME and 7.3 x 10(-8) M for CGE). The proposed potentiometric sensors manifest advantages of fast response and, most importantly, good selectivity with respect to many alkali, alkaline earth, transition, and heavy metal ions. The potentiometric responses of the electrodes are independent of the pH of the test solution in the pH range 2.9-3.7. The CGE was used in flow injection potentiometry and resulted in well defined peaks for uranyl ions with stable baseline, excellent reproducibility and very high sampling rate of 170 injections per hour. The proposed FIP system was used for the determination of trace uranyl ions in real and synthetic samples.
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http://dx.doi.org/10.1016/j.aca.2007.02.030 | DOI Listing |
Drug Discov Ther
December 2024
Department of Obstetrics and Reproductive Immunology, Shanghai East Hospital of Tongji University, Shanghai, China.
Acupuncture and traditional Chinese medicine (TCM) have shown certain benefits in assisted in vitro fertilization and embryo transfer (IVF-ET). In this study, we evaluated the efficacy and safety of the combination of acupuncture combined with the Bushen Quyu decoction in patients with failures of IVF-ET. This study was conducted at Shanghai Yangpu District Hospital of TCM from May to November of 2021.
View Article and Find Full Text PDFExp Eye Res
December 2024
Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, WI, 53226, USA; Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin, WI, 53226, USA. Electronic address:
Genome or prime editing has become a promising tool for the treatment of hereditary disorders affecting the inner retina, such as dominant optic neuropathies. In vivo delivery of gene editors, such as Cas9, is typically achieved using recombinant adeno-associated virus (rAAV) vectors, which have a broad range of cellular tropisms and are well tolerated following intravitreal administration. Owing to the large size of gene editing constructs and the limited carrying capacity of rAAV (<5.
View Article and Find Full Text PDFNeurobiol Dis
December 2024
Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany. Electronic address:
Increasing evidence points to infectious diseases as contributor to the pathogenesis of neurodegeneration in Parkinson's disease (PD), probably driven by a peripheral and CNS inflammatory response together with alpha-synuclein (aSyn) pathology. Pro-inflammatory lipopolysaccharide (LPS) endotoxin is suggested as a risk factor, and LPS shedding gram-negative bacteria are more prevalent in the gut-microbiome of PD patients. Here, we investigated whether LPS could contribute to the neurodegenerative disease progression via neuroinflammation, especially under conditions of aSyn pathology.
View Article and Find Full Text PDFMol Immunol
December 2024
Pharmacology of Chinese Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine of Shaanxi Administration of Traditional Chinese Medicine, Xianyang 712046, China; Engineering Research Center of Brain Health Industry of Chinese Medicine, Universities of Shaanxi Province, Xianyang 712046, China. Electronic address:
Background: PM2.5-induced brain damage is related to systemic inflammation and oxidative stress, which can be caused by PM2.5 acting directly on the brain or indirectly by stimulating inflammation in the peripheral nervous system; however, the underlying pathological mechanisms are still unclear.
View Article and Find Full Text PDFJ Control Release
December 2024
Department of Otolaryngology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Electronic address:
Background: Chronic rhinosinusitis (CRS) is an inflammatory disease characterized by persistent immune dysregulation, which presents considerable limitations in current medical therapy.
Objects: This study investigates a supramolecular gel (PSPD), which aims to minimize systemic adverse effects through local injection, provide long-lasting anti-inflammatory effects, and modulate the mucosal immune microenvironment.
Methods: The properties of PSPD were evaluated using rheological experiments.
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