AI Article Synopsis
- * As cells differentiate, they gradually lose stem cell-associated antigens and gain those of progenitor cells, which happens more as a continuous process than in clear-cut stages.
- * Variations in assay conditions can greatly affect the outcomes for these isolated cells, leading to differing interpretations of how lineage commitment occurs in blood cell development.
Article Abstract
Prospective isolation of hematopoietic stem and progenitor cell subsets depends upon the premise that expression of combinations of surface antigens reflects developmental potential. During the process of differentiation, however, the loss of antigens associated with stem cells and the concomitant gain of those associated with progenitor cells often occurs as a continuum rather than by discrete binary steps. Coupled with the fact that assay conditions can profoundly influence the developmental fates of prospectively isolated cells, gradients of antigen expression during differentiation have led to a variety of interpretations of lineage commitment in hematopoiesis.
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| http://dx.doi.org/10.1196/annals.1392.002 | DOI Listing |
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