A new xanthone named cratoxylumxanthone A (1), together with five known compounds: dulcisxanthone B (2), alpha-mangostin (3), beta-mangostin (4), 2-geranyl-1,3,7-trihydroxy-4-(3-methylbut-2-enyl)xanthone (5) and tectochrystin (6), was isolated from Cratoxylum cochinchinense stems. The structure of new compound was characterized by 1D and 2D NMR techniques. The isolated compounds showed free radical scavenging against DPPH and lipid peroxidation inhibition.
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Polyprenylated xanthones with potential anti-inflammatory and anti-HIV effects from the stems and leaves of (Lour.) Blume.
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Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, P. R. China.
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Zhongguo Zhong Yao Za Zhi
September 2023
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University Haikou 571127,China Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province, Hainan Normal University Haikou 571127,China Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University Haikou 571127,China.
Article Synopsis
- - Chemical compounds were extracted and identified from the stems and leaves of *Cratoxylum cochinchinense*, using various chromatography techniques, leading to the isolation of 21 different compounds.
- - Out of these, one compound was a new xanthone, while several others had not been previously identified in the *Cratoxylum* plant; some were newly discovered in *C. cochinchinense*.
- - The isolated compounds were assessed for their anti-rheumatoid arthritis effects, with xanthones 1-15 showing significant inhibition of synoviocyte proliferation, indicating potential therapeutic benefits.
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Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China.
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Division of Applied Life Science (BK21 Four), Institute of Agriculture and Life Science (IALS), Gyeongsang National University, Jinju, Republic of Korea.
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