The amelogenin protein is considered as the major molecular marker of developing ectodermal enamel. Recent data suggest other roles for amelogenin beyond structural regulation of enamel mineral crystal growth. Here we describe our novel discovery of amelogenin expression in long bone cells, in cartilage cells, in cells of the epiphyseal growth plate, and in bone marrow stromal cells.
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Endocytosis mediated by megalin and cubilin is involved in enamel development.
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Background: Endocytosis of enamel matrix proteins (EMPs) by ameloblasts is a key process in the mineralization of enamel during the maturation stage of amelogenesis. However, the relevant receptor mediating endocytosis of EMPs is still unclear. The aim of this study was to explore potential endocytic receptors involved in this process.
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[WWP1 plays a positive role in ameloblast differentiation and enamel formation in mice].
Zhonghua Kou Qiang Yi Xue Za Zhi
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State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan430079, China.
Article Synopsis
- The study focuses on the role of WWP1, a protein ligase, in the enamel development of mice.
- Single-cell RNA sequencing and immunohistochemistry showed that WWP1 is highly expressed in dental epithelial cells, specifically in ameloblasts involved in enamel formation.
- Wwp1 knockout mice displayed significant enamel developmental defects, including reduced enamel volume and disorganized enamel structures compared to control mice.
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Department of Forensic Medicine, University of Helsinki, Helsinki, Finland; Forensic Science Institute, Radford University, Radford, VA, USA. Electronic address:
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