Hypertrophic cardiomyopathy (HCM) is a frequently recognized condition on echocardiography. The apical variant, also known as 'Japanese variant', is rare and often poses a diagnostic challenge. There has been a resurgence of interest in the diagnosis of HCM especially with the advent of novel imaging modalities such as strain imaging. Two-dimensional (2D) strain echocardiography calculates tissue velocities via frame-to-frame tracking of acoustic markers within the image and provides strain parameters comparable with tissue-Doppler-derived strain. We describe paradoxical apical strain (systolic lengthening) without overt apical dyskinesis (conventional imaging) in two patients with apical HCM, using 2D strain imaging. Our report highlights a novel application of 2D strain imaging that could facilitate the diagnosis of apical HCM.
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http://dx.doi.org/10.1016/j.euje.2007.02.004 | DOI Listing |
Echocardiography
January 2025
Department of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Objectives: Supra-normal left ventricular ejection fraction (snLVEF) represents a heterogeneous group with distinct prognoses. Left atrial (LA) strain, measured by speckle tracking echocardiography (STE), is a validated prognostic indicator. This study aimed to evaluate LA and left ventricular (LV) mechanical strains in hypertensive patients with snLVEF.
View Article and Find Full Text PDFSTAR Protoc
January 2025
Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:
The eukaryotic cell division cycle is a highly conserved process, featuring fluctuations in protein localization and abundance required for key cell cycle transitions. Here, we present a protocol for the spatiotemporal analysis of the proteome during the budding yeast cell division cycle using live-cell imaging. We describe steps for strain construction, cell cultivation, microscopy, and image analysis.
View Article and Find Full Text PDFRSC Adv
January 2025
School of Material Science and Engineering, Nanjing Tech University P. R China.
Water pollution, oxidative stress and the emergence of multidrug-resistant bacterial strains are significant global threats that require urgent attention to protect human health. Nanocomposites that combine multiple metal oxides with carbon-based materials have garnered significant attention due to their synergistic physicochemical properties and versatile applications in both environmental and biomedical fields. In this context, the present study was aimed at synthesizing a ternary metal-oxide nanocomposite consisting of silver oxide, copper oxide, and zinc oxide (ACZ-NC), along with a multi-walled carbon nanotubes modified ternary metal-oxide nanocomposite (MWCNTs@ACZ-NC).
View Article and Find Full Text PDFActa Physiol (Oxf)
February 2025
PhyMedExp, IPAM/Biocampus, University of Montpellier, INSERM, CNRS., Montpellier, France.
Aim: Left atrial (LA) strain is emerging as a valuable metric for evaluating cardiac function, particularly under pathological conditions such as pressure overload. This preclinical study investigates the predictive utility of LA strain on cardiac function in a murine model subjected to pressure overload, mimicking pathologies such as hypertension and aortic stenosis.
Methods: High-resolution ultrasound was performed in a cohort of mice (n = 16) to evaluate left atrial and left ventricular function at baseline and 2 and 4 weeks after transverse aortic constriction (TAC).
Eur Heart J Cardiovasc Imaging
January 2025
School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Aim: To establish an imaging-based method to quantify left ventricular (LV) diastolic pressures.
Methods/results: In 115 patients suspected of coronary artery disease, LV pressure was measured by micromanometers and images by echocardiography. LV filling pressure was measured as LV pre-atrial contraction pressure (pre-A PLV).
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