Iconix Biosciences has developed leading products and services that apply novel and proprietary genomic technologies to profile candidate drug compounds in early discovery through to preclinical development, leading to a better understanding of candidate drugs in a faster, more cost-effective manner. The toxicology community is embracing this approach to increase the accuracy, sensitivity and speed of toxicity testing. Changing this paradigm will significantly impact the failure rate of late-stage preclinical compounds and provide a compelling return on investment. Through strategic growth and research, the company has identified the factors and is creating the environment that will lead to a 'tipping point' in the pharmaceutical and biotechnology industries, such that toxicogenomics becomes a standard practice in the drug discovery and development process.
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| http://dx.doi.org/10.2217/14622416.8.4.401 | DOI Listing |
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Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation.
Sci Signal
June 2021
Centre for Regenerative Medicine, Scottish Centre for Regenerative Medicine, Edinburgh, UK.
In the adult liver, a population of facultative progenitor cells called biliary epithelial cells (BECs) proliferate and differentiate into cholangiocytes and hepatocytes after injury, thereby restoring liver function. In mammalian models of chronic liver injury, Notch signaling is essential for bile duct formation from these cells. However, the continual proliferation of BECs and differentiation of hepatocytes in these models have limited their use for determining whether Notch signaling is required for BECs to replenish hepatocytes after injury in the mammalian liver.
View Article and Find Full Text PDFA transcriptomic analysis of black cohosh: Actein alters cholesterol biosynthesis pathways and synergizes with simvastatin.
Food Chem Toxicol
October 2018
Iconix/Entelos Biosciences, Mountain View, CA, 94043, USA.
Article Synopsis
- Previous research shows that black cohosh and its active compound actein can inhibit breast cancer cell growth and activate stress responses.
- This study examined how these substances affect gene expression in rat liver tissue, finding that black cohosh primarily activates RAR pathways while actein influences cholesterol biosynthesis.
- The findings suggest potential benefits of combining black cohosh with statins in cancer treatment, although caution is needed due to possible liver toxicity, highlighting the importance of further research on these herbal medicines.
A transcriptomic analysis of turmeric: Curcumin represses the expression of cholesterol biosynthetic genes and synergizes with simvastatin.
Pharmacol Res
June 2018
Iconix Biosciences, Mountain View, CA 94043, United States.
The spice turmeric (Curcuma longa L.) has a long history of use as an anti-inflammatory agent. The active component curcumin induces a variety of diverse biological effects and forms a series of degradation and metabolic products in vivo.
View Article and Find Full Text PDFThe liver pharmacological and xenobiotic gene response repertoire.
Mol Syst Biol
April 2008
Iconix Biosciences now Entelos, Foster City, CA, USA.
We have used a supervised classification approach to systematically mine a large microarray database derived from livers of compound-treated rats. Thirty-four distinct signatures (classifiers) for pharmacological and toxicological end points can be identified. Just 200 genes are sufficient to classify these end points.
View Article and Find Full Text PDFClinicopathological and tissue indicators of para-aminophenol nephrotoxicity in sprague-dawley rats.
Toxicol Pathol
June 2007
Department of Molecular and Investigative Toxicology, Iconix Biosciences, Inc., Mountain View, CA 94043, USA.
A model of para-aminophenol (PAP) nephrotoxicity in Sprague-Dawley rats was utilized to characterize potential indicators of toxicity in the kidney and in biofluids, and to chronicle the progression of acute renal injury. Rats were administered PAP at a low or high dose and examined terminally at 6, 24 and 48 hours (4 animals/group with matching controls). Acute tubular necrosis was observed in the medullary rays (low and high doses) and the outer stripe of outer medulla (high dose only) as early as 6 hours postdosing.
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