The reactions of 1,2- and 1,3-hydroxyalkyl azides and aldehydes in the presence of Lewis acid result in the one-step construction of oxazolines and dihydrooxazines, respectively. The reaction was adapted to parallel synthesis using a polymer-bound phosphine to scavenge excess hydroxyalkyl azide. Thus, a 60-member library of various disubstituted oxazolines and di- and trisubstituted dihydrooxazines was generated.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2539067 | PMC |
| http://dx.doi.org/10.1021/cc060159t | DOI Listing |
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