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Combined approach of nanoemulgel and microneedle pre-treatment as a topical anticellulite therapy.
ADMET DMPK
November 2024
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Background And Purpose: Cellulite is caused by changes in the metabolism of the fatty tissue beneath the skin. Methylxanthines and retinoids are commonly added to the different anticellulite products. However, their topical permeation into the dermis is limited.
View Article and Find Full Text PDFBowel preparation experiences and needs before follow-up colonoscopy in older adult postoperative colorectal cancer patients: A qualitative study.
World J Gastrointest Surg
September 2024
Department of Endoscopy, The Tongren Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200335, China.
Background: The bowel preparation process prior to colonoscopy determines the quality of the bowel preparation, which in turn affects the quality of the colonoscopy. Colonoscopy is an essential procedure for postoperative follow-up monitoring of colorectal cancer (CRC) patients. Previous studies have shown that advanced age and a history of colorectal resection are both risk factors for inadequate bowel preparation.
View Article and Find Full Text PDFDuring invisalign treatment, as salivary proteins or glycoproteins fill the space between the teeth and the aligners, they can easily adhere to the teeth, forming an acquired cellular film on which bacteria are highly susceptible to colonizing, which in turn leads to the development of enamel white staining lesions (WSLs), one of the major complications of orthodontic treatment. Inhibiting the activity of cariogenic bacteria while promoting the remineralization of demineralized enamel is the key to preventing and treating WSLs. Currently, the drug commonly used in clinical practice for the treatment of WSLs is silver diamine fluoride, which, although it has both antimicrobial and remineralizing effects, suffers from problems such as pulpal irritation and tooth discoloration.
View Article and Find Full Text PDFCosmetic considerations after breast cancer treatment.
Arch Dermatol Res
May 2024
Department of Dermatology, The Ohio State University Wexner Medical Center, 540 Officenter Place, Suite 240, Columbus, OH, 43230, USA.
Treatments for breast cancer can have an array of adverse effects, including hair loss, scarring, and irritated skin. These physical outcomes can, in turn, lead to body image concerns, anxiety, and depression. Fortunately, there is growing evidence that certain cosmetic therapies can improve patient self-image.
View Article and Find Full Text PDFChitosan/Pomegranate Seed Oil Emulgel Composition as a New Strategy for Dermal Delivery of Hydrocortisone.
Int J Mol Sci
March 2024
Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Białystok, Poland.
Article Synopsis
- Multifunctional delivery systems combining chitosan (CS) and pomegranate seed oil (PO) have shown potential in enhancing drug release and providing additional therapeutic effects.
- This research focused on developing topical emulgels with hydrocortisone to evaluate how different CS/PO weight ratios impact drug absorption and anti-inflammatory efficacy.
- Results indicated that the emulgel with a CS/PO ratio of 6:4 provided the best drug release rate, increased anti-inflammatory effects, and demonstrated low toxicity to skin cells.
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