Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/ncpneph0442 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sequential administration of paricalcitol followed by IL-17 blockade for progressive refractory IgA nephropathy patients.
Sci Rep
February 2024
Gastroenterology Department, Hospital Universitario de Cáceres, Cáceres, Spain.
There is no established treatment for progressive IgA nephropathy refractory to steroids and immunosuppressant drugs (r-IgAN). Interleukin 17 (IL-17) blockade has garnered interest in immune-mediated diseases involving the gut-kidney axis. However, single IL-17A inhibition induced paradoxical effects in patients with Crohn's disease and some cases of de novo glomerulonephritis, possibly due to the complete Th1 cell response, along with the concomitant downregulation of regulatory T cells (Tregs).
View Article and Find Full Text PDFComparative Effectiveness of Alternative Treatment Approaches to Secondary Hyperparathyroidism in Patients Receiving Maintenance Hemodialysis: An Observational Trial Emulation.
Am J Kidney Dis
January 2024
Departments of Medicine and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia. Electronic address:
Rationale & Objective: Optimal approaches to treat secondary hyperparathyroidism (SHPT) in patients on maintenance hemodialysis (HD) have yet to be established in randomized controlled trials (RCTs).
Study Design: Two observational clinical trial emulations.
Setting & Participants: Both emulations included adults receiving in-center HD from a national dialysis organization.
Impact of vitamin D deficiency on mouse sperm structure and function.
Andrology
September 2020
Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.
Background: In rodents and humans, vitamin D deficiency (VDD) is associated with altered sperm structure and function (primarily decreased motility and morphological abnormalities) that are primarily attributed to VDD-induced hypocalcemia. However, it is suspected that VDD has much more drastic effects on mammalian spermatozoa.
Objectives: The purpose of this study was to illustrate that VDD, depending on its severity and duration, can alter sperm nuclear integrity and can also lead to the loss of spermatozoa's ability to support embryonic development.
Active Vitamin D in Chronic Kidney Disease: Getting Right Back Where We Started from?
Kidney Dis (Basel)
March 2019
Renal Division, Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
Background: The vitamin D system is essential for optimal health in humans. Circulating calcitriol, a key metabolite in maintaining calcium and phosphorus homeostasis, is produced in the kidney. In kidney failure, calcitriol levels progressively decrease, contributing to the development of renal secondary hyperparathyroidism (SHPT).
View Article and Find Full Text PDFA Bayesian network analysis on comparative efficacy of treatment strategies for dialysis patients with secondary hyperparathyroidism.
Exp Ther Med
January 2019
Nephrology Department, The First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China.
For dialysis patients with end-stage kidney disease and secondary hyperparathyroidism (SHPT), there are three therapeutic treatment options: Cinacalcet, paricalcitol and cinacalcet plus low-dose vitamin D analogues. However, their comparative efficacy remains unclear at present. Thus, in the current study, a Bayesian network analysis was conducted to evaluate the relative efficacy and safety of these three therapeutic regimens.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!