Three Akt isoforms differentially control cell survival, growth, proliferation, metabolism, and motility. In this issue of Molecular Cell, Brognard et al. (2007) report that two PHLPP phosphatases specifically downregulate the Akts to control the activity of isoform-specific substrates.
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| http://dx.doi.org/10.1016/j.molcel.2007.03.007 | DOI Listing |
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