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Non-tuberculous mycobacterial shoulder arthritis with acute exacerbation soon after initiation of immune checkpoint inhibitor: A case report.
J Infect Chemother
December 2024
Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan.
Immune checkpoint inhibitors (ICIs) have been approved for treating various cancers; however, they can cause immune-related adverse events. Generally, ICIs are not associated with an increased risk of infection, however, several reports demonstrated infections caused by nontuberculous mycobacterium (NTM) during ICI therapy. Here, we report a case of NTM shoulder arthritis with acute exacerbation immediately after ICI initiation.
View Article and Find Full Text PDFMycobacterial avium intracellulare (MAI) extensor tenosynovitis of wrist: An uncommon entity.
Radiol Case Rep
February 2025
Department of Medical Imaging,St. Joseph's Health Care London, 268 Grosvenor St, London, Ontario, Canada, N6A 4V2.
Rice bodies secondary to synovial inflammation, typically occur in the shoulders and knees of individuals affected by either rheumatoid arthritis or tuberculosis. It is uncommon to encounter these in nontubercular mycobacterial tenosynovitis especially in wrist extensor compartment. Understanding this condition and its distinctive imaging features is crucial for both treating clinicians and radiologists.
View Article and Find Full Text PDFAltered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study.
Lancet Microbe
November 2024
Division of Infection and Immunity, University College London, London, UK. Electronic address:
Article Synopsis
- The study investigates the relationship between IL-6 signaling, particularly through the SNP rs2228145, and the risk of developing tuberculosis (TB), considering that inhibitors of IL-6 signaling might increase TB progression risk.
- The researchers conducted a meta-analysis of various genome-wide association studies (GWAS) to analyze genetic data and extract effect estimates related to the C allele of rs2228145, which is associated with reduced IL-6 signaling.
- Preliminary findings include data from 17 GWAS, covering a substantial sample of individuals with tuberculosis and a large control population, aiming to understand how genetic factors might influence TB susceptibility.
Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis.
Biol Trace Elem Res
November 2024
Heavy Metal and Preventive Toxicology Lab, Department of Toxicology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.
Zinc aspartate and zinc citrate have been used as zinc supplements in different health conditions. Taking into consideration their anti-inflammatory, immunomodulatory, anti-oxidant and antimicrobial properties, the present study has been designed to analyse the effect of zinc aspartate and zinc citrate treatment at therapeutic dose level on disease severity index, haematological, serological, antimicrobial and radiological markers of rheumatoid arthritis in Wistar rats. Bactericidal potential of the two organic zinc compounds was analysed in vitro in clinically isolated Escherichia coli.
View Article and Find Full Text PDFNon-tuberculous mycobacterial bone and joint infections - a case series from a tertiary referral centre in Australia.
ANZ J Surg
November 2024
Infectious Diseases Unit, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Background: Non-tuberculous mycobacteria (NTM) are rare causes of bone and joint infection (BJI) and there is limited evidence on which to base management decisions. This study describes 1 year of experience from a multi-disciplinary BJI team which collects data on all cases reviewed at a tertiary referral centre in Queensland, Australia.
Methods: The database was interrogated for all cases in which NTM were recovered from operative samples.
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