AI Article Synopsis
- CD8 T cells that target self-antigens exist in the peripheral lymphoid system and can play a role in autoimmune diseases or transplant rejection.
- The outcome of CD8 T cell activation—whether they become fully activated or tolerant—is influenced by the presence of specific cytokines during key response stages.
- Essential signals from cytokines like IL-12, IFN-alpha/beta, and IL-2 are crucial for the activation and proliferation of these T cells, shedding light on how they contribute to autoimmunity and transplant rejection.
Article Abstract
CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the response. Signals provided by IL-12 and/or IFN-alpha/beta are required for activation of naïve CD8 T cells, and IL-2 is needed to sustain and further expand the effector cells if Ag persists. These critical signaling requirements provide new insights into the factors that regulate the CD8 T cell contributions to development of autoimmunity or rejection of transplants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955740 | PMC |
| http://dx.doi.org/10.1016/j.smim.2007.02.007 | DOI Listing |
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