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Challenges in "probing spectroscopic probes" for noninvasive simultaneous disease diagnosis.
Front Chem
January 2025
Department of Chemical and Biological Sciences, S. N. Bose National Centre for Basic Sciences, Kolkata, India.
Noninvasive diagnosis of human diseases relies on the detection of molecular markers (probes) in a painless manner. Although extrinsic and intrinsic molecular markers are often used, intrinsic disease probes (molecular markers) are preferable because they are naturally present in our body, and deviation in their concentration from normal levels clearly indicates anomalies in human bodies, that is, diseases. In this study, we report noninvasive spectroscopic measurements of total haemoglobin (Hb), bilirubin, and the ratio of oxy- and deoxyhaemoglobin as disease markers for anaemia, jaundice, and oxygen deficiency, respectively, using a meticulously designed optical fibre probe.
View Article and Find Full Text PDFBSA/PEI/GOD modified cellulose nanocrystals for construction of hydrogel-based flexible glucose sensors for sweat detection.
J Mater Chem B
January 2025
School of Chemistry and Materials Science, Ludong University, Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province, Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Yantai 264025, China.
With the miniaturization, integration and intelligence of sweat electrochemical sensor technology, hydrogel flexible sensors have demonstrated immense potential in the field of real-time and non-invasive personal health monitoring. However, it remains a challenge to integrate excellent mechanical properties, self-healing properties, and electrochemical sensing capabilities into the preparation of hydrogel-based flexible sensors. The utilization of CBPG (cellulose nanocrystals (CNCs)@bovine serum albumin (BSA)@polyethyleneimine (PEI) glucose oxidase (GOD) nanomaterial) as both an enhancing phase and sensor probe within a hydrogel matrix, with poly(vinyl alcohol) (PVA) serving as the primary network constituent, has been proposed as a non-invasive technique for monitoring trace glucose levels in sweat.
View Article and Find Full Text PDFThe fibronectin-targeting PEG-FUD imaging probe shows enhanced uptake during fibrogenesis in experimental lung fibrosis.
Respir Res
January 2025
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Avenue, Madison, WI, 53792, USA.
Progressive forms of interstitial lung diseases, including idiopathic pulmonary fibrosis (IPF), are deadly disorders lacking non-invasive biomarkers for assessment of early disease activity, which presents a major obstacle in disease management. Excessive extracellular matrix (ECM) deposition is a hallmark of these disorders, with fibronectin being an abundant ECM glycoprotein that is highly upregulated in early fibrosis and serves as a scaffold for the deposition of other matrix proteins. Due to its role in active fibrosis, we are targeting fibronectin as a biomarker of early lung fibrosis disease activity via the PEGylated fibronectin-binding polypeptide (PEG-FUD).
View Article and Find Full Text PDFDetection and genomic characterisation of foot-and-mouth disease virus serotypes circulating in Cameroon using environmental sampling.
Sci Rep
January 2025
The Pirbright Institute, Ash Road, Pirbright, Surrey, GU24 0NF, UK.
Foot-and-mouth disease virus (FMDV) is a highly contagious, economically important disease of livestock and wildlife species. Active monitoring and understanding the epidemiology of FMDV underpin the foundations of control programmes. In many endemic areas, however, veterinary resources are limited, resulting in a requirement for simple sampling techniques to increase and supplement surveillance efforts.
View Article and Find Full Text PDFCD45-PET is a robust, non-invasive tool for imaging inflammation.
Nature
January 2025
Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensitivity and clarity in several preclinical models.
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