The proteome of the Thai cobra, Naja kaouthia, venom, revealed by two-dimensional liquid chromatography/tandem mass spectrometry, was found to consist of peptides which could be matched with 61 proteins in the database. These proteins were classified into 12 groups according to the differences in their biological activities: cardiotoxins, cobra venom factors, a cysteine-rich toxin, cytotoxins, kaouthiagin, mocarhagin, muscarinic toxin-like proteins, neurotoxins, an oxoglutarate dehydrogenase, phospholipases, serum albumin, and a weak toxin. Horse derived- anti-N. kaouthia venom hyperimmune serum currently used for the treatment of cobra ophitoxaemia reacted only to the cobra venom factors and phospholipases in the cobra holovenom by two-dimensional gel electrophoresis based-immunoblotting. The venom proteomic insight of this study should pave the way for preparing a therapeutic anti-venom of improved quality, i.e. also containing antibodies to the newly revealed toxic, but poorly immunogenic, minor venom components. It is expected that such a preparation should have a higher effectiveness than the currently used anti-venom in resuscitating cobra-bite victims.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.toxicon.2007.01.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Paralysis and Necrotic Wound Infection Resulting From Monocled Cobra Envenomation.
Cureus
November 2024
Department of Emergency and Hospital Medicine, Division of Medical Toxicology, Lehigh Valley Health Network/University of South Florida Morsani College of Medicine, Allentown, USA.
Non-native snake envenomations can be difficult to manage because of challenges obtaining appropriate antivenom and unfamiliarity with the expected clinical effects. This case report describes a 37-year-old man who was envenomated by his pet monocled cobra (). He experienced respiratory failure, requiring intubation and mechanical ventilation.
View Article and Find Full Text PDFBehavioral and hormonal responses in the defensive repertoire during provocation in captive monocled cobra (Naja kaouthia).
Physiol Behav
December 2024
Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Henry Dunant Rd., Pathumwan, Bangkok 10330, Thailand. Electronic address:
The hooding behavior exhibited by cobras is a distinct defensive mechanism against predators, encompassing both visual and auditory displays. This behavior can be triggered by natural predators or humans. Considering that human provocation may potentially stimulate the hypothalamic-pituitary-adrenal (HPA) axis, the present study aimed to determine the pattern of the HPA axis response following human provocation-induced hooding behavior (PV) and provide a detailed analysis of the behavioral PV displays.
View Article and Find Full Text PDFFrequency, geographical distribution, clinical characteristics, antivenom utilisation and outcomes of King Cobra (Ophiophagus hannah) bites in Malaysia.
PLoS Negl Trop Dis
July 2024
Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Article Synopsis
- - Snakebite envenomation is a major but often overlooked public health issue in tropical and subtropical regions, with particular challenges in medical infrastructure and record-keeping, especially concerning the King Cobra in Malaysia.
- - A study from 2015 to 2020 analyzed 32 cases of King Cobra bites, primarily occurring in Peninsular Malaysia, where most victims attempted to catch or interact with the snake, leading to significant symptoms like ptosis and requiring advanced medical interventions.
- - Most patients received antivenom treatment, primarily the monospecific King Cobra antivenom, but the study noted one death due to severe complications, highlighting the need for better public awareness and timely treatment to improve outcomes.
() sp. nov. (Nematoda: Trichuroidea): a new nematode in from Thailand.
Parasitology
April 2024
Animal Systematics & Molecular Ecology Laboratory and Applied Animal Science Laboratory, Department of Biology, Faculty of Science, Mahidol University, Bangkok, Thailand.
A comprehensive investigation, incorporating both morphological and molecular analyses, has unveiled the existence of a hitherto unknown nematode species, () sp. nov., residing in the intestine of the monocled cobra, , in the central region of Thailand.
View Article and Find Full Text PDFDevelopment of a Biosensor to Detect Venom of Malayan Krait ().
Toxins (Basel)
January 2024
Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathumthani 12120, Thailand.
Article Synopsis
- * Administering 10 vials of antivenom is recommended for envenomed victims without neurotoxic symptoms, but excessive antivenom can cause adverse reactions; thus, monitoring venom levels is crucial.
- * This study developed a biosensor using gold electrodes coated with krait antivenom to effectively detect venom in rat plasma, demonstrating a potential new tool for improving the treatment of krait envenoming.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!