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J Med Chem
January 2025
College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
The P2YR is activated by UDP and UDP glucose and is involved in many human inflammatory diseases. Based on the molecular docking analysis of currently reported P2YR antagonists and the crystallographic overlap study between PPTN and compound , a series of 3-substituted 5-amidobenzoate derivatives were designed, synthesized, and identified as promising P2YR antagonists. The optimal compound (methyl 3-(1-benzo[]imidazol-2-yl)-5-(2-(-tolyl) acetamido)benzoate, IC = 0.
View Article and Find Full Text PDFFront Public Health
January 2025
Party Committee Office, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Background: This study aimed to investigate and analyze the current status of oral disease treatment among the older adult in Guangxi Zhuang Autonomous Region, while also assessing the continuing medical education (CME) needs of dental institution personnel regarding oral diseases in this population.
Methods: Convenience sampling was used to investigate the oral disease treatment among older adults and to assess CME needs of dental institution personnel regarding oral diseases in this population across various oral medical and health institutions in Guangxi.
Results: A total of 754 valid questionnaires were collected, of which 70.
Digit Health
January 2025
School of Public Affairs, Zhejiang University, Hangzhou, China.
This letter addresses the integration of artificial intelligence and the Internet of Things-based older adult healthcare programs with existing community and institutional elderly care systems. It highlights the current disconnect leading to service duplication and resource inefficiencies, proposes multifaceted integration approaches, and underscores the importance of supportive policies. International examples are referenced to demonstrate successful models, emphasizing the need for coordinated care to enhance service delivery and optimize resource use.
View Article and Find Full Text PDFNiger Med J
January 2025
Department of Obstetrics and gynecology, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria.
Abdominal ectopic pregnancy is a rare type of ectopic pregnancy associated with high maternal and perinatal mortality. We present a case of a 28-year-old now primipara who was misdiagnosed to have abruptio placentae and ruptured uterus on two different occasions from a primary health care center but was found to have an advanced abdominal ectopic gestation at 21 weeks gestational age. The patient was managed by exploratory laparotomy and is currently doing well.
View Article and Find Full Text PDFDiabetol Int
January 2025
Teikyo University Graduate School of Public Health, Itabashi-ku, Tokyo Japan.
Aim: Oral health is important in patients with diabetes. While health literacy may promote preventive dental visits, the evidence is sparse among them. Additionally, because education is indicated as a determinant of health literacy, none clarified whether health literacy can mitigate educational inequalities in healthcare-seeking behaviors.
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